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Regulation of the Lung Inflammatory Response

  • P. A. Ward
  • A. B. Lentsch
Conference paper

Abstract

Lung inflammatory responses in rat lung induced by deposition of IgG immune complexes are associated with complement activation, influx of neutrophils, activation of pulmonary macrophages and ensuing injury of the lung parenchyma [1]. Injury in this model is associated with extravascular leak of albumin, development of haemorrhage and damage of cellular and matrix constituents. Tissue injury is likely due to the combined effects of oxidants and proteases released from activated lung macrophages and from recruited neutrophils following a complex sequence of cellular and mediator interactions [2]. Essential to an understanding of these inflammatory events is the relationship between lung macrophage production of cytokines [such as tumor necrosis factor-alpha (TNFα) and interleukin-1 (IL-1)] and the response of the lung vasculature, the result of which is upregulation of endothelial adhesion molecules, including intercellular adhesion molecule-1 (ICAM-1) and E-selectin. We have found that these lung inflammatory reactions are carefully self-regulated. That is to say, the intensity of the inflammatory response builds up to a crescendo, peaking between 3–4 hours, then rapidly diminishes, as reflected by a reduction in vascular permeability, a cessation in haemorrhage and no further accumulation of neutrophils [3]. In some manner, then, these inflammatory responses are under regulatory control that ensures the potentially destructive inflammatory response will be contained.

Keywords

NFKB Activation Endothelial Adhesion Molecule Lung Macrophage Vascular Adhesion Molecule Complement Activation Product 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Italia, Milano 1999

Authors and Affiliations

  • P. A. Ward
  • A. B. Lentsch

There are no affiliations available

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