Genetic Predisposition to Sepsis and Organ Failure
Sepsis and organ failure continue to challenge practitioners of critical care and their patients. The purpose of this brief review is to explore emerging information about genetic predisposition to sepsis and organ failure. For this discussion, we will define a continuum from sepsis through organ failure to represent a set of responses to infection and ischemia which, left unchecked, ordinarily results in severe disability or death. These responses are presently thought to represent a dysregulated synthesis of pro- and anti-inflammatory responses chronicled elsewhere in this volume.
KeywordsSevere Sepsis Organ Failure Cerebral Malaria Meningococcal Disease Polymorphic Allele
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