Genetic Predisposition to Sepsis and Organ Failure

  • B. A. Zehnbauer
  • B. D. Freeman
  • T. G. Buchman
Conference paper


Sepsis and organ failure continue to challenge practitioners of critical care and their patients. The purpose of this brief review is to explore emerging information about genetic predisposition to sepsis and organ failure. For this discussion, we will define a continuum from sepsis through organ failure to represent a set of responses to infection and ischemia which, left unchecked, ordinarily results in severe disability or death. These responses are presently thought to represent a dysregulated synthesis of pro- and anti-inflammatory responses chronicled elsewhere in this volume.


Severe Sepsis Organ Failure Cerebral Malaria Meningococcal Disease Polymorphic Allele 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Italia, Milano 1999

Authors and Affiliations

  • B. A. Zehnbauer
  • B. D. Freeman
  • T. G. Buchman

There are no affiliations available

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