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Inflammation: How Much Is Too Much and Can It Be Controlled?

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Sepsis and Organ Dysfunction

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Abstract

The human immune response to infection includes an orchestration of various specific and non-specific soluble factors and cellular elements. The appropriate response leads to efficient control of infection or repair of injury; but when this response is too little or too much it may result in a completely different outcome. An attenuated immune defense leads to poor healing and prolonged infection. By contrast, an exaggerated response may result in shock and multi-system organ failure [1–3]. It is a balanced and regulated immune cascade which most predictably leads to recovery. Among the areas of most intense current interest is an understanding of the mechanics which promote such activation and control of the immune response to inflammation.

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Authors
  1. V. Rumalla
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  2. S. F. Lowry
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Editors and Affiliations

  1. Department of Surgery, Saint Louis University, Health Sciences Center, St. Louis, USA

    A. E. Baue M.D.

  2. Department of Anaesthesia, Intensive Care and Pain Therapy, University of Trieste, Cattinara Hospital, Trieste, Italy

    G. Berlot M.D.  & A. Gullo M.D.  & 

  3. Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Belgium

    J.-L. Vincent M.D.

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Rumalla, V., Lowry, S.F. (1999). Inflammation: How Much Is Too Much and Can It Be Controlled?. In: Baue, A.E., Berlot, G., Gullo, A., Vincent, JL. (eds) Sepsis and Organ Dysfunction. Springer, Milano. https://doi.org/10.1007/978-88-470-2248-5_2

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  • DOI: https://doi.org/10.1007/978-88-470-2248-5_2

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