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From Cytokines through Immune Effector Cells to the Body

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Sepsis and Organ Dysfunction

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Abstract

All forms of severe insult to the body, from trauma, burns, sepsis, and pancreatitis are associated with the activation and systemic expression of host inflammatory pathways via stimulation of the host immune effector cells to synthesize and release potent mediators of cell inflammation [1], This generalized process is often referred to as the systemic inflammatory response syndrome(SIRS) [2] to identify the non-specific aspects of its expression. Although the initial mediators of this process are often cytokines produced specifically in response to a pro-inflammatory stimulus, subsequently a vast array of protein and lipid mediator species is expressed in a complex network that at present defies simple description [3, 4]. The initiating cytokine usually is tumor necrosis factor-α (TNF-α) which induces a generalized up-regulation of the inflammatory cascades through binding to specific cell membrane receptors on immune competent cells.

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References

  1. Schlag G, Redl H (1996) Mediators of injury and inflammation. World J Surg 20:406–410

    Article  PubMed  CAS  Google Scholar 

  2. Bone RC (1996) Toward a theory regarding the pathogenesis of the systemic inflammatory response syndrome: what we do and do not know about cytokine regulation. Crit Care Med 24: 163–172

    Article  PubMed  CAS  Google Scholar 

  3. Marsh CB, Wewers MD (1996) The pathogenesis of sepsis. Factors that modulate the response to gram-negative bacterial infection. Clin Chest Med 17:183–197

    Article  PubMed  CAS  Google Scholar 

  4. Crowley SR (1996) The pathogenesis of septic shock. Heart Lung 25:124–134

    Article  PubMed  CAS  Google Scholar 

  5. Pinsky MR, Vincent JL, Deviere J et al (1993) Serum cytokine levels in human septic shock. Relation to multiple-system organ failure and mortality. Chest 103:565–575

    Article  PubMed  CAS  Google Scholar 

  6. Thijs LG, Hack CE (1995) Time course of cytokine levels in sepsis. Intensive Care Med 21 [Suppl 2]:S258–S263

    Article  PubMed  Google Scholar 

  7. Blackwell TS, Christman JW (1996) Sepsis and cytokines: current status. Br J Anaesth 77: 110–117

    PubMed  CAS  Google Scholar 

  8. Goldie AS, Fearon KC, Ross JA et al (1995) Natural cytokine antagonists and endogenous anti-endotoxin core antibodies in sepsis syndrome. The Sepsis Intervention Group. JAMA 274:172–117

    Article  PubMed  CAS  Google Scholar 

  9. Vanderpoll T, Malefyt RD, Coyle SM, Lowry SF (1997) Anti-inflammatory cytokine responses during clinical sepsis and experimental endotoxemia. Sequential measurements of plasma soluble interleukin(IL)-l receptor type li, IL-10, and IL-13. J Infect Dis 175:118–122

    Article  CAS  Google Scholar 

  10. Ertel W, Scholl FA, Trentz O (1996) The role of anti-inflammatory mediators for the control of systemic inflammation following severe injury. In: Faist E, Baue AE, Schildberg FW (eds) The immune consequences of trauma, shock, and sepsis. Mechanisms and therapeutic approaches. Pabst Science Publishers, Lengerich, pp 453–470

    Google Scholar 

  11. Cavaillon JM (1995) The nonspecific nature of endotoxin tolerance. Trends Microbiol 3: 320–324

    Article  PubMed  CAS  Google Scholar 

  12. Ziegler-Heitbrock HWL, Wedel A, Schraut W et al (1994) Tolerance to lipopolysaccharide involves mobilization of nuclear factor kB with predominance of p 50 homodimers. J Biol Chem 269:17001–17004

    PubMed  CAS  Google Scholar 

  13. Larue KEA, McCall CE (1994) A liable transcriptional repressor modulates endotoxin tolerance. J Exp Med 180:2269–2275

    Article  PubMed  CAS  Google Scholar 

  14. Pinsky MR (1994) Clinical studies on cytokines in sepsis: role of serum cytokines in the development of multiple-systems organ failure. Nephrol Dial Transplant 9[Suppl 4]:94–98

    PubMed  Google Scholar 

  15. Martich GD, Boujoukos AJ, Suffredini AF (1993) Response of man to endotoxin. Immunobiology 187:403–416

    Article  PubMed  CAS  Google Scholar 

  16. Boutten A, Dehoux MS, Seta N et al (1996) Compartmentalized IL-8 and elastase release within the human lung in unilateral pneumonia. Am J Respir Crit Care Med 153:336–342

    PubMed  CAS  Google Scholar 

  17. Hauser CJ (1996) Regional macrophage activation after injury and the compartmentalization of inflammation in trauma. New Horiz 4:235–251

    PubMed  CAS  Google Scholar 

  18. Rosenbloom AJ, Pinsky MR, Bryant JL et al (1995) Leukocyte activation in the peripheral blood of patients with cirrhosis of the liver and SIRS. Correlation with serum interleukin-6 levels and organ dysfunction. JAMA 274:58–65

    Article  PubMed  CAS  Google Scholar 

  19. Tschaikowsky K, Sittl R, Braun GG et al (1993) Increased fMet-Leu-Phe receptor expression and altered superoxide production of neutrophil granulocytes in septic and posttraumatic patients. J Clin Invest 72:18–25

    Google Scholar 

  20. Trautinger F, Hammerle AF, Poschl G, Micksche M (1991) Respiratory burst capability of polymorphonuclear neutrophils and TNF-alpha serum levels in relationship to the development of septic syndrome in critically ill patients. J Leukoc Biol 49:449–454

    PubMed  CAS  Google Scholar 

  21. Wenisch C, Parschalk P, Hasenhundl M et al (1995) Polymorphonuclear leukocyte dysregula-tion in patients with gram-negative septicemia assessed by flow cytometry. Eur J Clin Invest 25:418–424

    Article  PubMed  CAS  Google Scholar 

  22. McCall CE, Grosso-Wilmoth LM, LaRue K et al (1993) Tolerance to endotoxin-induced expression of the interleukin-1 beta gene in blood neutrophils of humans with the sepsis syndrome. J Clin Invest 91:853–861

    Article  PubMed  CAS  Google Scholar 

  23. Vespasiano MC, Lewandoski JR, Zimmerman JJ (1993) Longitudinal analysis of neutrophil superoxide anion generation in patients with septic shock. Crit Care Med 21:666–672

    Article  PubMed  CAS  Google Scholar 

  24. Sorrell TC, Sztelma K, May GL (1994) Circulating polymorphonuclear leukocytes from patients with gram-negative bacteremia are not primed for enhanced production of leukotriene B4 or 5-hydroxyeicosatetraenoic acid. J Infect Dis 169:1151–2114

    Article  PubMed  CAS  Google Scholar 

  25. Nakae H, Endo S, Inada K et al (1996) Changes in adhesion molecule levels in sepsis. Res Commun Mol Pathol Pharmacol 91:329–338

    PubMed  CAS  Google Scholar 

  26. Fasano MB, Cousart S, Neal S, McCall CE (1991) Increased expression of the interleukin 1 receptor on blood neutrophils of humans with the sepsis syndrome. J Clin Invest 88: 1452–2149

    Article  PubMed  CAS  Google Scholar 

  27. Brom J, Koller M, Schlüter B et al (1995) Expression of the adhesion molecule CD11b and polymerization of actin by polymorphonuclear granulocytes of patients endangered by sepsis. Burns 21:427–431

    Article  PubMed  CAS  Google Scholar 

  28. Ljunghusen O, Berg S, Hed J et al (1995) Transient endotoxemia during burn wound revision causes leukocyte beta 2 integrin up-regulation and cytokine release. Inflammation 19:457–468

    Article  PubMed  CAS  Google Scholar 

  29. Lin RY, Astiz ME, Saxon JC et al (1994) Relationships between plasma cytokine concentrations and leukocyte functional antigen expression in patients with sepsis. Crit Care Med 22:1595–1602

    PubMed  CAS  Google Scholar 

  30. Lin RY, Astiz ME, Saxon JC, Rackow EC (1993) Altered leukocyte immunophenotypes in septic shock. Studies of HLA-DR, CD11b, CD14, and IL-2R expression. Chest 104:847–853

    Article  PubMed  CAS  Google Scholar 

  31. Rosenbloom AJ, Levann D, Ray B et al (1996) Density and avidity changes of Cd11b on circulating polymorphonuclear leukocytes(PMN) in systemic inflammatory response syndrome(SIRS). Am J Respir Crit Care Med 153(4):A123(abstract)

    Google Scholar 

  32. Polla BS, Jacquier-Sarlin MR, Kantengwa S et al (1996) TNF-α alters mitochondrial membrane potential in L929 but not in TNF-α-resistance L929.12 cells: relationship with the expression of stress proteins, annexin 1 and superoxide dismutase activity. Free Radic Res 25: 125–131

    Article  PubMed  CAS  Google Scholar 

  33. Munoz C, Carlet J, Fitting C et al (1991) Dysregulation of vitro cytokine production by monocytes during sepsis. J Clin Invest 88:1747–1754

    Article  PubMed  CAS  Google Scholar 

  34. Jaaettla M, Wising D (1993) Heat shock proteins protect cells from monocyte cytotoxicity: possible mechanism of self protection. J Exp Med 177:231–236

    Article  Google Scholar 

  35. Bellmann K, Wenz A, Radons J et al (1995) Heat shock induces resistance in rat pancreatic islet cells against nitric oxide, oxygen radicals and streptozototocin toxicity in vitro. J Clin Invest 95:2840–2845

    Article  PubMed  CAS  Google Scholar 

  36. Malyshev IY, Malugin AV, Golubeva LY et al (1996) Nitric oxide donor induces HSP70 accumulation in the heart and in cultured cells. FEBS Lett 391:21–23

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. M. R. Pinsky
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Editor information

Editors and Affiliations

  1. Department of Surgery, Saint Louis University, Health Sciences Center, St. Louis, USA

    A. E. Baue M.D.

  2. Department of Anaesthesia, Intensive Care and Pain Therapy, University of Trieste, Cattinara Hospital, Trieste, Italy

    G. Berlot M.D.  & A. Gullo M.D.  & 

  3. Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Belgium

    J.-L. Vincent M.D.

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© 1999 Springer-Verlag Italia, Milano

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Pinsky, M.R. (1999). From Cytokines through Immune Effector Cells to the Body. In: Baue, A.E., Berlot, G., Gullo, A., Vincent, JL. (eds) Sepsis and Organ Dysfunction. Springer, Milano. https://doi.org/10.1007/978-88-470-2248-5_15

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  • DOI: https://doi.org/10.1007/978-88-470-2248-5_15

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-0052-0

  • Online ISBN: 978-88-470-2248-5

  • eBook Packages: Springer Book Archive

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