New and Old Markers in Sepsis

  • K. Reinhart
  • W. Karzai
Conference paper


Sepsis is defined as a systemic response to severe infections. Sepsis is diagnosed when clinical evidence of infection is accompanied by signs of systemic inflammation. These statements have been translated to a set of clinical and laboratory criteria helpful for the diagnosis of sepsis. Ten years ago, clinical investigators started using uniform diagnostic criteria for including large numbers of patients in multicenter immunomodulatory trials of sepsis [1]. These studies provided a valuable database which helped define what sepsis means when certain diagnostic(study entry) criteria are used. Based on the characteristics of the placebo arm of one of these trials, Roger Bone published important clinical data regarding the epidemiology of sepsis(as defined by those criteria) and proposed using a set of criteria for “early detection and treatment of a group of very high-risk patients with sepsis” [2]. Since it was recognized that sepsis is a syndrome and not a disease, he coined the term “sepsis syndrome” for this group of patients.


Septic Shock Severe Sepsis Sepsis Syndrome Procalcitonin Level Septic Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Italia, Milano 1999

Authors and Affiliations

  • K. Reinhart
  • W. Karzai

There are no affiliations available

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