“Untimely Apoptosis” Is the Password

  • T. G. Buchman
Conference paper


Multiple organ failure (also known as the multiple organ dysfunction syndrome [MODS]) remains a formidable foe. Despite advances in critical care including scoring systems, predictive models, monitoring, imaging and specific interventions, the mortality of multiple organ failure remains paradoxically high. The purpose of this brief chapter is to review what is known and consider what might be determined regarding apoptosis in MODS.


Multiple Organ Failure Multiple Organ Dysfunction Syndrome Pyrrolidine Dithiocarbamate Sustained Inflammation Accelerate Apoptosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Cobb JP, Hotchkiss RS, Karl IE, Buchman TG (1996) Mechanisms of cell injury and death. Br J Anaesth 77:3–10PubMedGoogle Scholar
  2. 2.
    Mandai M, Maggirwar SB, Sharma N et al (1996) Bcl-2 prevents CD95 (Fas/APO-1)-induced degradation of lamin B and poly(ADP-ribose) polymerase and restores the NF-kappaB signaling pathway. J Biol Chem 271:30354–30359CrossRefGoogle Scholar
  3. 3.
    Le Page C, Sanceau J, Drapier JC, Wietzerbin J (1998) Inhibitors of ADP-ribosylation impair inducible nitric oxide synthase gene transcription through inhibition of NF kappa B activation. Biochem Biophys Res Commun 243:451–457PubMedCrossRefGoogle Scholar
  4. 4.
    Chitnis D, Dickerson C, Munster AM, Winchurch RA (1996) Inhibition of apoptosis in polymorphonuclear neutrophils from burn patients. J Leukoc Biol 59:835–839PubMedGoogle Scholar
  5. 5.
    Biffi WL, Moore EE, Moore FA, Barnett CC Jr (1996) Interleukin-6 delays neutrophil apoptosis via a mechanism involving platelet-activating factor. J Trauma 40:575–578CrossRefGoogle Scholar
  6. 6.
    Hotchkiss RS, Swanson PE, Cobb JP et al (1997) Apoptosis in lymphoid and parenchymal cells during sepsis: findings in normal and T-and B-cell-deficient mice. Crit Care Med 25:1298–1307PubMedCrossRefGoogle Scholar
  7. 7.
    Ayala A, Herdon CD, Lehman DL et al (1995) The induction of accelerated thymic programmed cell death during polymicrobial sepsis: control by corticosteroids but not tumor necrosis factor. Shock 3:259–267PubMedCrossRefGoogle Scholar
  8. 8.
    DeMeester SL, Buchman TG, Qiu Y et al (1998) Pyrrolidine dithiocarbamate activates the heat shock response and thereby induces apoptosis in primed endothelial cells. Shock 10:1–6PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Italia, Milano 1999

Authors and Affiliations

  • T. G. Buchman

There are no affiliations available

Personalised recommendations