Apoptosis (Programmed Cell Death) and the Resolution of Acute Inflammation

  • A. H. Rouzati
  • R. Taneja
  • J. C. Marshall
Conference paper


Biology, for the clinician, has classically encompassed the study of the life and growth of cells and organisms; death has been perceived as a pathologic process to be prevented. But over the past few years, our perception of cell death has undergone a major transformation [1]. It is now recognized that cells do not have an absolute and unchangeable lifespan, but rather that cell survival can change in response to environmental stimuli. Moreover, a moment’s reflection will confirm that for a host of normal biologic processes, controlled cellular death is not only inevitable, but critical to normal development. During embryogenesis, the formation of mature organs is dependent on the controlled remodeling of tissues resulting, for example, in the formation of interdigital web spaces or the canalization of the gastrointestinal tract. Deletion of autoreactive T cells during immune maturation is essential to prevent autoimmune disease; other tissues such as blood cells, and epithelial cells of the skin, or gastrointestinal tract are constantly formed and shed during life. The programmed death of cells is called apoptosis.


Systemic Inflammatory Response Syndrome Granulocyte Colony Stimulate Factor Respir Crit Adult Respiratory Distress Syndrome Neutrophil Apoptosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Italia, Milano 1999

Authors and Affiliations

  • A. H. Rouzati
  • R. Taneja
  • J. C. Marshall

There are no affiliations available

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