Neurobiology of rhIGF-I: Rationale for Use in Motor Neuron Disease
Recombinant human insulin-like growth factor I (rhIGF-I) is a 70 aminoacid protein with a molecular weight of approximately 7.6 kilodaltons. It was originally identified and isolated based on endocrine and metabolic similarities it shared with insulin, particularly those related to the control of blood sugar. However, intense research has demonstrated that IGF-I is mechanistically, biochemically, and pharmacologically distinct from insulin.
KeywordsAmyotrophic Lateral Sclerosis Motor Neuron Sciatic Nerve Grip Strength Motor Neuron Disease
Unable to display preview. Download preview PDF.
- 2.Sara VR, Hall K, Von Holtz H, Humbel RE, Sjogren B, Wetterberg L (1982) Evidence of the presence of specific receptors for insulin-like growth factors 1 (IGF-1) and 2 (IGF-2) and insulin throughout the adult human brain. Neurosci Lett 34: 38–44Google Scholar
- 4.Baron-Van Evercoon B-A, Olichon-Berthe C, Kowalski A, Visciano G, Van Obberghen E (1991) Expression of IGF-I and insulin receptor genes in the rat central nervous system: a developmental, regional, and cellular analysis. J Neurosci Res 28: 244–253Google Scholar
- 5.Kar S, Chabot J-G, Quirion R (1993) Quantitative autoradiographic localisation of [125I]insulin-like growth factor I, [125I]insulin-like growth factor II, and [125I]insulin receptor binding sites in developing and adult rat brain. Comp Neurol 333: 375–397Google Scholar
- 11.Gruner JA, Wagner L, Bhat RV, Contreras PC, Miller MS (1997) rhIGF-I promotes motoneuron survival following neonatal sciatic transection. 27th Annual Meeting, Society for Neuroscience, October 25–30,1997, New Orleans, A248. 19Google Scholar
- 13.Dengler R, Konstanzer A, Kuther G, Hesse S, Wolf W, Struppler A (1990) Amyotrophic lateral sclerosis: Macro-EMG and twitch forces of single motor units. Muscle Nerve 13: 545–550Google Scholar
- 17.Contreras PC, Steffier C, Yu E, Callison K, Stong D, Vaught J (1995) Systemic administration of rhIGF-I enhanced regeneration after sciatic nerve crush in mice. J Pharmacol Exp Therap 274: 1443–1499Google Scholar
- 20.Gorio A, Vergani L, Losa M, Pezzoni G, Calvano L, Finco C, Di Giulio AM, Torsello A, Mtiller EE (1998) IGF-I and glycosaminoglycans improve peripheral nerve regeneration and motor neuron survival in models of motor neuron disease. In: Müller EE (ed) IGFs in the Nervous System. Springer-Verlag, Berlin Heidelberg New York, pp 84–85Google Scholar