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The Potential of IGF-I as a Neuronal Rescue Agent

  • P. D. Gluckman
  • C. E. Williams
  • J. Guan
  • A. Scheepens
  • R. Zhang
  • V. Russo
  • G. Werther

Abstract

Acute brain injury leads to neuronal and glial death in two phases occurring during and immediately after the insult (assuming the insult is reversed), termed primary neuronal death, and that occurring some hours to days after the injury, termed delayed cell death [1]. The mechanisms contributing to primary cell loss include glutamate toxicity, intracellular calcium accumulation, free radical formation, membrane lipid peroxidation, cytotoxic edema and cell lysis. Programmed cell death (apoptosis) is the most important factor contributing to delayed cell death although the cytotoxic consequences of microglial activation and glutamate toxicity associated with postasphyxiai seizures also play a role.

Keywords

Acute Brain Injury Fetal Sheep Delay Cell Death Selective Neuronal Loss Neuronal Rescue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Italia, Milano 1998

Authors and Affiliations

  • P. D. Gluckman
    • 1
  • C. E. Williams
    • 1
  • J. Guan
    • 1
  • A. Scheepens
    • 1
  • R. Zhang
    • 1
  • V. Russo
    • 2
  • G. Werther
    • 2
  1. 1.Research Centre for Developmental Medicine and BiologyUniversity of AucklandAucklandNew Zealand
  2. 2.Department of PaediatricsRoyal Childrens HospitalMelbourneAustralia

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