The Potential of IGF-I as a Neuronal Rescue Agent
Acute brain injury leads to neuronal and glial death in two phases occurring during and immediately after the insult (assuming the insult is reversed), termed primary neuronal death, and that occurring some hours to days after the injury, termed delayed cell death . The mechanisms contributing to primary cell loss include glutamate toxicity, intracellular calcium accumulation, free radical formation, membrane lipid peroxidation, cytotoxic edema and cell lysis. Programmed cell death (apoptosis) is the most important factor contributing to delayed cell death although the cytotoxic consequences of microglial activation and glutamate toxicity associated with postasphyxiai seizures also play a role.
KeywordsAcute Brain Injury Fetal Sheep Delay Cell Death Selective Neuronal Loss Neuronal Rescue
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