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Expression of IGF-I and IGF-I Receptor mRNA in Sural Nerves of Diabetic Patients

  • M. Grandis
  • L. Nobbio
  • G. L. Mancardi
  • M. Abbruzzese
  • E. Maritato
  • L. Banchi
  • A. Schenone

Abstract

The insulin-like growth factors (IGF-I, IGF-II) are polypeptides with both; growth-promoting and insulin-like metabolic activities [1]. IGFs, whose expression is considerable in the developing nervous system [2], have neurotrophic actions in motor [3], sensory [3] and sympathetic neurons [3–4]. Since these neural populations result to be damaged in diabetic neuropathy, it has been proposed that a loss of IGFs may be involved in the pathogenesis of this common complication of diabetes.

Keywords

Diabetic Neuropathy Sural Nerve Axonal Neuropathy Sural Nerve Biopsy Semiquantitative Reverse Transcriptase Polymerase Chain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Italia, Milano 1998

Authors and Affiliations

  • M. Grandis
    • 1
  • L. Nobbio
    • 1
  • G. L. Mancardi
    • 1
  • M. Abbruzzese
    • 1
  • E. Maritato
    • 2
  • L. Banchi
    • 1
  • A. Schenone
    • 1
  1. 1.Department of Neurological Sciences and NeurorehabilitationUniversity of GenoaGenovaItaly
  2. 2.Institute of Surgical AnatomyUniversity of GenoaGenovaItaly

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