Expression of IGF-I and IGF-I Receptor mRNA in Sural Nerves of Diabetic Patients

  • M. Grandis
  • L. Nobbio
  • G. L. Mancardi
  • M. Abbruzzese
  • E. Maritato
  • L. Banchi
  • A. Schenone


The insulin-like growth factors (IGF-I, IGF-II) are polypeptides with both; growth-promoting and insulin-like metabolic activities [1]. IGFs, whose expression is considerable in the developing nervous system [2], have neurotrophic actions in motor [3], sensory [3] and sympathetic neurons [3–4]. Since these neural populations result to be damaged in diabetic neuropathy, it has been proposed that a loss of IGFs may be involved in the pathogenesis of this common complication of diabetes.


Diabetic Neuropathy Sural Nerve Axonal Neuropathy Sural Nerve Biopsy Semiquantitative Reverse Transcriptase Polymerase Chain 
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Copyright information

© Springer-Verlag Italia, Milano 1998

Authors and Affiliations

  • M. Grandis
    • 1
  • L. Nobbio
    • 1
  • G. L. Mancardi
    • 1
  • M. Abbruzzese
    • 1
  • E. Maritato
    • 2
  • L. Banchi
    • 1
  • A. Schenone
    • 1
  1. 1.Department of Neurological Sciences and NeurorehabilitationUniversity of GenoaGenovaItaly
  2. 2.Institute of Surgical AnatomyUniversity of GenoaGenovaItaly

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