Abstract
Insulin-like growth factor I (IGF-I) is a protein implicated in the regulation of several growth processes. Specifically, IGF-I mediates the action of growth hormone (GH) on its target organs and regulates both the release of somatostatin and GH from the hypothalamus and the release of GH and prolactin from the pituitary gland [1]. Moreover, it exerts a tissue-specific autocrine and paracrine role during the course of normal growth and differentiation [2]. IGF-I also plays a physiological role in the central nervous system (CNS) both during early development and adulthood [3-5]. Alteration in the level of IGF-I during early postnatal life is correlated with several brain dysfunctions [4]. IGF-I appears to participate in normal CNS development by regulating neuronal survival and differentiation and by stimulating glial growth [6]; postnatal synthesis of IGF-I has been detected in brain regions characterised by life-long processes of synapse formation, suggesting an additional role for this peptide in promoting and maintaining neuronal plasticity. Moreover, transgenic mice overexpressing IGF-I have significantly larger brains than controls, likely a result of increased cell size and number [7], while homozygous IGF-I (-/-) mice show reduced brain weights at 2 months of age [8].
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Berelowitz M, Szabo M, Frohman LA, Firestone S, Chu L, Hintz RL (1981) Somatomedin - C mediates growth hormone negative feedback by effects on both the hypothalamus and the pituitary Science 212: 1279–1281
Holly JMP, Wass JHA (1989) Insulin-like growth factors: autocrine paracrine or endocrine? New perspectives of the somatomedin hypothesis in the light of recent development. J Endocrinol 122: 611–618
Baskin DG, Wilcox BJ, Figlewicz DP, Dorsa DM (1988) Insulin and insulin-like growth factors in CNS. Trends Neurosci 11: 107–111
Sara VR, Carlsson-Skwirut C (1988) The role of insulin-like growth factors in the regulation of brain development. Prog Brain Res 73: 87–99
Bondy CA (1991) Transient IGF-I gene expression during the maturation of functionally related central projection neurons. J Neurosci 11: 3442–3455
Torres-Aleman I, Naftolin F, Robbins RJ (1990) Trophic effects of insulin-like growth factor-I on fetal rat hypothalamic cells in culture. Neuroscience 3: 601–608
Carson M, Behringer RR, Brinster RL, McMorris FA (1993) Insulin-like growth factor I increases brain growth and central nervous system myelination in transgenic mice. Neuron 10: 729–740
Beck KD, Powell-Braxton L, Widmer HR, Valverde J, Hefti F (1995) Igfl gene disruption results in reduced brain size, CNS hypomyelination, and loss of hippocampal granule and striatal parvalbumin-containing neurons. Neuron 14: 717–730
Alleva E, Aloe L, Calamandrei G (1987) Nerve growth factor influences neurobeha- vioral development of newborn mice. Neurotoxicol Teratol 9: 271–275
Philipps AF, Persson B, Hall K, Lake M, Skottner A, Sanagen T, Sara VS (1988) The effects of biosynthetic insulin-like growth factor-I supplementation on somatic growth, maturation and erythropoiesis of the neonatal rat. Pediatr Res 23: 298–305
Calamandrei G, Alleva E (in press) Growth factors in neurobehavioral development. In: Cosmi EV, Di Renzo GC, Hawkins DH (eds) Recent advances in perinatal medicine. Academic Publishers, London
Santucci D, Calamandrei G, Cagiano R (1994) IGF-I and IGF-I24–41, but not IGF-I57 70 affect somatic and neurobehavioral development of newborn male mice. Brain Res Bull 35: 367–371
Fox M (1965) Reflex-ontogeny and behavioural development of the mouse. Anim Behav 13: 234–241
Elwood RW, Keeling F (1982) Temporal organization of ultrasonic vocalization in infant mice. Dev Psychobiol 15: 221–227
Cagiano R, Sales GD, Renna G, Racagni G, Cuomo V (1986) Ultrasonic vocalization in rat pups: effects of early postnatal exposure to haloperidol. Life Sci 38: 1417–1423
Santucci D, Calamandrei G, Alleva E (1993) Neonatal exposure to bFGF exerts NGF- like effects on mouse behavioral development. Neurotoxicol Teratol 15: 131–137
Noldus LP (1991) The observer: A software system for collection and analysis of observational data. Behav Res Met Inst Comp 23: 415–429
Chiarotti F, Alleva E, Bignami G (1987) Problems of test choice and data analysis in behavioral teratology: The case of prenatal benzodiazepines. Neurotoxicol Teratol 9: 179–186
Knusel B, Michel PP, Schwaber JS, Hefti F (1990) Selective and nonselective stimulation of central cholinergic and dopaminergic development in vitro by nerve growth factor, basic fibroblast growth factor, epidermal growth factor, insulin and the insulin-like growth factors I and II. J Neurosci 10: 558–570
Konishi Y, Takahashi K, Chui DH, Rosenfeld RG, Himeno M, Tabira T. (1994) Insulinlike growth factor II promotes in vitro cholinergic development of mouse septal neurons: comparison with the effect of insulin-like growth factor I. Brain Res 649: 53–61
Holtzman DM, Santucci D, Kilbridge J, Couzens JC, Fontana DJ, Daniels SE, Johnson RM, Chen K, Sun Y, Carlson E, Alleva E, Epstein CJ, Mobley WC (1996) Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome. Proc Natl Acad Sci USA 93: 13333–13338
Ricceri L, Calamandrei G, Berger-Sweeney J (1997) Different effects of postnatal day 1 vs 7 192 IgG sapor in lesions on learning, exploratory behavior and neurochemistry in juvenile rats. Behav Neurosci (in press)
Everitt BJ, Robbins TW, (1997) Central cholinergic systems and cognition. Annu Rev Psychol 48:649–684
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1998 Springer-Verlag Italia, Milano
About this chapter
Cite this chapter
Santucci, D., Luoni, M., Torsello, A., Branchi, I., Mùller, E.E., Alleva, E. (1998). Anti-Insulin-like Growth Factor I Antibodies Affect Locomotion and Passive Avoidance Performances in Sprague-Dawley Rats. In: Müller, E.E. (eds) IGFs in the Nervous System. Springer, Milano. https://doi.org/10.1007/978-88-470-2246-1_12
Download citation
DOI: https://doi.org/10.1007/978-88-470-2246-1_12
Publisher Name: Springer, Milano
Print ISBN: 978-3-540-75042-0
Online ISBN: 978-88-470-2246-1
eBook Packages: Springer Book Archive