New Experimental Models for the Study of IGF and IGF-Binding Protein Action in the Brain

  • M. Holzenberger
  • E. Gay
  • S. Doublier
  • M. Binoux


Insulin-like growth factors (IGF) I and II, along with their receptors and binding proteins form the IGF system which regulates important aspects of embryonic and postnatal growth in vertebrates [1]. The IGF system was initially described and studied in detail under its endocrine aspects. The recent discovery of important paracrine and autocrine IGF signalling has contributed substantially to understanding the complex biological actions of the IGFs. Expression of components of the IGF system in embryonic, postnatal and adult central nervous system (CNS) tissues, and their action on cultured neurones and glia have suggested a key role in development and maintenance of the brain [2–6].


Olfactory Bulb Neuronal Replacement High Vocal Centre Olfactory Bulb Mitral Cell Brain Growth Retardation 
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Copyright information

© Springer-Verlag Italia, Milano 1998

Authors and Affiliations

  • M. Holzenberger
    • 1
  • E. Gay
    • 1
  • S. Doublier
    • 1
  • M. Binoux
    • 1
  1. 1.INSERM U.142Hôpital Saint-AntoineParisFrance

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