Abstract
Interest in the possible role of antioxidant vitamins in the prevention of heart disease has recently awakened in the medical and research community. Vitamin C in particular, however, has lagged behind lipid-soluble antioxidants, particularly vitamin E and carotenoids, in terms of the research conducted and the general impression of the strength of its role. Before reviewing the existing data, it may be useful to describe some of the reasons why there is a paucity of research and a generally unenthusiastic attitude in the medical and clinical trial community.
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References
Block G, Sinha R, Gridley G (1994) Collection of dietary-supplement data and implications for analysis. Am J Clin Nutr 59:232S–239S
Simon JA (1992) Vitamin C and cardiovascular disease: a review. Am J Clin Nutr 11:107–125
Heine H, Norden C (1979) Vitamin C therapy in hyperlipoproteinemia. Int J Vitam Nutr Res 19:45–54
Horsey J, Livesley B, Dickerson JWT (1981) Ischaemic heart disease and aged patients: effects of ascorbic acid on lipoproteins. J Hum Nutr 35:53–58
Buzzard IM, McRoberts MR, Driscoll DL, Bowering J (1982) Effect of dietary eggs and ascorbic acid on plasma lipid and lipoprotein cholesterol levels in healthy young men. Am J Clin Nutr 36:94–105
Jacques PF, Hartz SC, McGandy RB, Jacob RA, Russell RM (1987) Vitamin C and blood lipoproteins in an elderly population. Ann NY Acad Sci 498:100–109
Block G, Mangels AR, Patterson BH et al (1997) Effect of body weight and prior depletion on blood ascorbate levels attained on several vitamin C dosages: a controlled diet study. Am J Clin Nutr (in press)
Mangels AR, Block G, Frey CM et al (1993) The bioavailability to humans of ascorbic acid from oranges, orange juice and cooked broccoli is similar to that of synthetic ascorbic acid. J Nutr 123:1054–1061
Joffres MR, Reed DM, Yano K (1987) Relationship of magnesium intake and other dietary factors to blood pressure: the Honolulu Heart Study. Am J Clin Nutr 45:469–475
Harlan WR, Hull AL, Schmouder RL, Landis JR, Thompson FE, Larkin FA (1984) Blood pressure and nutrition in adults. The National Health and Nutrition Eamination Survey. Am J Epidemiol 120:17–28
Stanton JL, Braitman LE, Riley AM, Khoo C, Smith JL (1982) Demographic, dietary, life style, and anthropometric correlates of blood pressure. Hypertension 4[Suppl III]:135–142
McCarron DA, Morris CD, Henry HJ, Stanton JL (1984) Blood pressure and nutrient intake in the United States. Science 224:1392–1398
Koh ET, Chi MS (1980) Relationship of serum vitamin C and globulin fractions with anthropometric measurements in adults. Nutr Rep Int 21:537–549
Koh ET, Stewart T (1978) Interrelationship among the blood components and anthropometric measurements. Nutr Rep Int 18:539–548
Melby CL, Toohey ML, Cebrick J (1994) Blood pressure and blood lipids among vegetarian, semivegetarian, and nonvegetarian African Americans. Am J Clin Nutr 59:103–109
Jacques PF (1992) A cross-sectional study of vitamin C intake and blood pressure in the elderly. Int J Vitam Nutr Res 62:252–255
Salonen JT, Salonen R, Ihanainen M et al (1988) Blood pressure, dietary fats, and antioxidants. Am J Clin Nutr 48:1226–1232
Yoshioka M, Matsushita T, Chuman Y (1984) Inverse association of serum ascorbic acid level and blood pressure or rate of hypertension in male adults aged 30–39 years. Int J Vitam Nutr Res 54:343–347
Ness AR, Khaw K, Bingham S, Day N (1996) Vitamin C status and blood pressure. J Hypertens 14:503–508
Choi ESK, Jacques PF, Dallai PF, Jacob RA (1991) Correlation of blood pressure with plasma ascorbic acid. Nutr Res 11:1377–1382
Riemersma RA, Oliver M, Elton RA et al (1990) Plasma antioxidants and coronary heart disease: vitamins C and E and selenium. Eur J Clin Nutr 44:143–150
Moran JP, Cohen L, Greene JM et al (1993) Plasma ascorbic acid concentrations relate inversely to blood pressure in human subjects. Am J Clin Nutr 57:213–217
Yoshioka M, Matsushita T, Chuman Y (1984) Inverse association of serum ascorbic acid level and blood pressure of rate of hypertension in male adults aged 30–39 years. Int J Vitam Nutr Res 54:343–347
Cohen L, Feldman EB, Feldman DS, Harnes CG (1990) Dietary antioxidants and blood pressure. Am J Clin Nutr 50:511 (abstr)
Wen Y, Killalea S, McGettigan P, Feely J (1996) Lipid peroxidation and antioxidant vitamins C and E in hypertensive patients. Ir J Med Sci 165:210–212
Mark SD, Wang W, Fraumeni JF Jr et al (1996) Lowered risks of hypertension and cerebrovascular disease after vitamin/mineral supplementation: The Linxian Nutrition Intervention Trial. Am J Epidemiol 143:658–664
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© 1998 Springer-Verlag Italia, Milano
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Block, G. (1998). Vitamin C and Cardiovascular Risk Factors. In: Paoletti, R., Sies, H., Bug, J., Grossi, E., Poli, A. (eds) Vitamin C. Springer, Milano. https://doi.org/10.1007/978-88-470-2244-7_6
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DOI: https://doi.org/10.1007/978-88-470-2244-7_6
Publisher Name: Springer, Milano
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