Vitamin C pp 41-49 | Cite as

Vitamin C and Gastric Cancer Prevention

  • C. J. Schorah
Conference paper


It is now recognised that carcinogenesis is a multi-step process occurring over several decades [1]. The mechanism probably involves initiation, a primary DNA mutation which affects the rate of cell division; promotion, increased activity of factors which encourage the cell to divide; and progression, further changes in the structure of DNA which lead to malignancy through loss of control of cell division. Although such a description is an over-simplification, it shows that current thinking puts modifications to the structure of DNA at the heart of the carcinogenic process.


Gastric Cancer Gastric Juice Atrophic Gastritis Gastric Carcinogenesis Carcinogenic Process 
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  1. 1.
    Weinberg RA (1989) Oncogenes, antioncogenes and the molecular basis of multi-step carcinogenesis. Cancer Res 49:3713–3721PubMedGoogle Scholar
  2. 2.
    Schorah CJ (1995) Micronutrients, antioxidants and risk of cancer. Bibl Nutr Dieta 52:92–107PubMedGoogle Scholar
  3. 3.
    Guyton KZ, Kensler TW (1993) Oxidative mechanisms in carcinogenesis. Br Med Bull 49:523–544PubMedGoogle Scholar
  4. 4.
    Dizdaroglu M (1993) Chemistry of free radical damage to DNA. In: Halliwell B, Aruoma OI (eds) DNA and free radicals. Ellis Horwood, Chichester, pp 19–39Google Scholar
  5. 5.
    Frei B, England L, Ames BN (1989) Ascorbate is an outstanding antioxidant in human blood plasma. Proc Natl Acad Sci USA 86:6377–6381PubMedCrossRefGoogle Scholar
  6. 6.
    Liebler DC, Kling DS, Reed DJ (1986) Antioxidant protection of phospholipid bilayer by α-tocopherol: control of tocopherol status and lipid peroxidation by ascorbic acid and glutathione. J Biol Chem 261:12114–12119PubMedGoogle Scholar
  7. 7.
    Block G, Patterson B, Subar A (1992) Fruit, vegetables and cancer prevention: a review of the epidemiological evidence. Nutr Cancer 18:1–29PubMedCrossRefGoogle Scholar
  8. 8.
    Ziegler RG (1991) Vegetables, fruit and carotenoids and risk of cancer. Am J Clin Nutr 53:251S–259SPubMedGoogle Scholar
  9. 9.
    Stahlin HB, Gey KF, Eicholzer M, Ludin E, Bernasconi F, Thurneysen J, Brubacher G (1991) Plasma antioxidant vitamins and subsequent cancer mortality in the 12 y case follow-up of the prospective Basel study. Am J Epidemiol 133:766–775Google Scholar
  10. 10.
    Block G (1992) Vitamin C and cancer prevention: the epidemiological evidence. Nutr Cancer 18:1–29PubMedCrossRefGoogle Scholar
  11. 11.
    Cohen M, Bhagavan HN (1995) Ascorbic acid and gastrointestinal cancer. J Am Coll Nutr 14:565–578PubMedGoogle Scholar
  12. 12.
    Sobala GM, Schorah CJ, Sanderson M, Dixon MF, Tomkins DS, Godwin P, Axon ATR (1989) Ascorbic acid in the human stomach. Gastroenterology 97:357–363PubMedGoogle Scholar
  13. 13.
    Waring AJ, Drake IM, Schorah CJ, White KLM, Lynch DAF, Axon ATR, Dixon MF (1996) Ascorbic acid and total vitamin C concentrations in plasma, gastric juice and gastrointestinal mucosa: effects of gastritis and oral supplementation. Gut 38:171–176PubMedCrossRefGoogle Scholar
  14. 14.
    Correa P (1995) Helicobacter pylori and gastric carcinogenesis. Am J Surg Pathol 19:S37-S43PubMedCrossRefGoogle Scholar
  15. 15.
    Forman D (1996) Helicobacter pylori and gastric cancer. Scand J Gastroenterol 215:48–51CrossRefGoogle Scholar
  16. 16.
    Sobala GM, Crabtree JE, Dixon MF, Schorah CJ, Taylor JD, Rathbone BJ, Heatley RV, Axon ATR (1991) Acute Helicobacter pylori infection: clinical features, local and systemic immune response, gastric mucosal histology, and gastric juice ascorbic acid concentrations. Gut 32:1415–1418PubMedCrossRefGoogle Scholar
  17. 17.
    Inoue M, Tajima K, Kobayashi S, Suzuki T, Matsuura A, Nakamura J, Shirai M, Nakamura S, Inuzuka K, Tominaga S (1996) Protective factor against progression from atrophic gastritis to gastric cancer-data from a cohort study in Japan. Int J Cancer 66:309–314PubMedCrossRefGoogle Scholar
  18. 18.
    Schorah CJ, Sobala GM, Sanderson M, Collis N, Primrose JN (1991) Gastric juice, ascorbic acid: effects of disease and implications for gastric carcinogenesis. Am J Clin Nutr 53:287S–293SPubMedGoogle Scholar
  19. 19.
    O’Toole P, Lombard M (1996) Vitamin C and gastric cancer: supplements for some or fruit for all. Gut 39:345–347PubMedCrossRefGoogle Scholar
  20. 20.
    Drake IM, Davies MJ, Mapstone NP, Dixon MF, Schorah CJ, White KLM, Chalmers DM, Axon ATR (1996) Ascorbic acid may protect against human gastric cancer by scavenging mucosal oxygen radicals. Carcinogenesis 17:559–562PubMedCrossRefGoogle Scholar
  21. 21.
    Farinati F, Delia Libera G, Cardin R, Molari A, Plebani M, Rugge M, Di Mario F, Naccamto R (1996) Gastric antioxidants, nitrites and mucosal lipoperoxidation in chronic gastritis and Helicobacter pylori infection. J Clin Gastroenterol 22:275–281PubMedCrossRefGoogle Scholar
  22. 22.
    Xu GP, Song PJ, Reed PI (1993) Effects of fruit juices, processed vegetable juice, orange peel and green tea on endogenous formation of N-nitrosoproline in subjects from high-risk areas for gastric cancer in Moping County, China. Eur J Cancer Prev 2:327–335PubMedCrossRefGoogle Scholar
  23. 23.
    Mirvish SS (1994) Experimental evidence for inhibition of N-nitroso compound formation as a factor in the negative correlation between vitamin C consumption and the incidence of certain cancers. Cancer Res 54:1948S–1951SPubMedGoogle Scholar
  24. 24.
    Kyrptopoulous SA, Pignatelli B, Karkanias G, Golematis B, Esteve J (1991) Studies in gastric carcinogenesis. V. The effects of ascorbic acid on N-nitroso compound formation in human gastric juice in vivo and in vitro. Carcinogenesis 12:1371–1376CrossRefGoogle Scholar
  25. 25.
    Blot WJ, Li JY, Taylor PR, Guo W, Dawsey S, Wang GQ, Yang CS, Zheng SUF, Gail M, Li GY, Yu Y, Liu BQ, Tangrea J, Sun YH, Liu F, Fraumeni J, Zhang YH, Li B (1993) Nutrition intervention trials in Linxian, China. J Natl Cancer Inst 85:1483–1492PubMedCrossRefGoogle Scholar
  26. 26.
    Tsugane S, Tsubono Y, Okubos S, Hayashi M, Kakizoe T (1996) A pilot study for a randomised controlled trial to prevent gastric cancer in a high risk population: study design and feasibility evaluation. Japn J Cancer Res 87:676–679CrossRefGoogle Scholar
  27. 27.
    de Sanjose S, Munoz N, Sobala G, Vivas J, Peraza S, Cano E, Castro D, Sanchez V, Andrade O, Tomkins D, Schorah CJ, Axon ATR, Benz M, Oliver W (1996) Antioxidants, Helicobacter pylori and stomach cancer in Venezuela. Eur J Cancer Prev 5:57–62PubMedCrossRefGoogle Scholar
  28. 28.
    Sobala GM, Schorah CJ, Shires S, Lynch DAF, Gallacher B, Dixon MF, Axon ATR (1993) Effect of eradication of Helicobacter pylori on gastric juice ascorbic acid concentrations. Gut 34:1038–1041PubMedCrossRefGoogle Scholar
  29. 29.
    Sobala GM, Schorah CJ, Pignatelli B, Crabtree JE, Martin IG, Scott N, Quirke P (1993) High gastric juice ascorbic acid concentrations in members of a gastric cancer family. Carcinogenesis 14:291–292PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Italia, Milano 1998

Authors and Affiliations

  • C. J. Schorah
    • 1
  1. 1.Division of Clinical Sciences (Chemical Pathology), The Old Medical SchoolUniversity of LeedsLeedsUK

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