Vitamin C pp 13-20 | Cite as

Modulation of Cell Death by Oxidants and Antioxidants

  • M. B. Hampton
  • S. Orrenius
Conference paper


Excessive oxidative stress kills cells. Until recently, however, the mode of cell death was largely ignored. Today, the study of cell death itself is one of the most rapidly growing areas in biomedical research. It is recognized that many compounds, rather than being directly cytotoxic, actually cause sublethal damage that triggers an innate suicide program in the cell. This process, termed apoptosis, is important during development, in maintaining tissue homeostasis, and also for removing damaged, infected, or potentially neoplastic cells.


Reactive Oxygen Species Reactive Oxygen Species Production Thiol Oxidation Excessive Oxidative Stress Maintain Tissue Homeostasis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Italia, Milano 1998

Authors and Affiliations

  • M. B. Hampton
    • 1
  • S. Orrenius
    • 2
  1. 1.Department of PathologyChristchurch School of MedicineChristchurchNew Zealand
  2. 2.Institute of Environmental Medicine, Division of ToxicologyKarolinska InstitutetStockholmSweden

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