The pathophysiology of sepsis and multiple organ failure (MOF) remains the subject of intense investigation, and, despite extensive studies, MOF is still a clinical dilemma. The syndrome involves the progressive — and sometimes sequential — dysfunction of physiologic systems in the presence of a clinical picture of systemic sepsis [1–4]. It occurs with distressing frequency in patients after treatment of major injuries and operations for intra-abdominal emergencies or sepsis, and its mortality rate increases progressively with the number of organs involved [2, 3]. Furthermore, the pathophysiology of this syndrome and, thus, specific prophylaxis and treatment remain elusive, and the disappointing results of recent clinical trials of anti-endotoxin antibodies emphasize the incomplete understanding of this problem .
KeywordsNitric Oxide Total Parenteral Nutrition Multiple Organ Failure Orotic Acid Selective Digestive Decontamination
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