Bacterial Translocation

  • G. Sganga
  • H. K. F. van Saene
  • G. Brisinda
  • M. Castagneto
Conference paper
Part of the Topics in Anaesthesia and Critical Care book series (TIACC)


The pathophysiology of sepsis and multiple organ failure (MOF) remains the subject of intense investigation, and, despite extensive studies, MOF is still a clinical dilemma. The syndrome involves the progressive — and sometimes sequential — dysfunction of physiologic systems in the presence of a clinical picture of systemic sepsis [1–4]. It occurs with distressing frequency in patients after treatment of major injuries and operations for intra-abdominal emergencies or sepsis, and its mortality rate increases progressively with the number of organs involved [2, 3]. Furthermore, the pathophysiology of this syndrome and, thus, specific prophylaxis and treatment remain elusive, and the disappointing results of recent clinical trials of anti-endotoxin antibodies emphasize the incomplete understanding of this problem [5].


Nitric Oxide Total Parenteral Nutrition Multiple Organ Failure Orotic Acid Selective Digestive Decontamination 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Italia, Milano 2001

Authors and Affiliations

  • G. Sganga
  • H. K. F. van Saene
  • G. Brisinda
  • M. Castagneto

There are no affiliations available

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