Multi-Drug-Resistant Staphylococci and Enterococci

  • G. L. French
Conference paper
Part of the Topics in Anaesthesia and Critical Care book series (TIACC)


The introduction of penicillin and other early antimicrobials in the 1940s and 1950s revolutionised the treatment of gram-positive bacterial infections, especially skin and wound infections with Staphylococcus aureus and Streptococcus pyogenes,and community-acquired pneumonia due to Streptococcus pneumoniae With the exception of S. aureus, penicillin resistance in these organisms was uncommon. Furthermore, a wide choice of agents for the treatment of gram-positive infections soon became available, including the penicillins, cephalosporins, sulphonamides, macrolides, lincosamines, tetracyclines, rifamycins and fusidic acid. Some of the agents introduced later for the treatment of gram-negative infections, such as the aminoglycosides and quinolones, also had useful gram-positive activity. With such a wide choice of treatment, antibiotic resistance in gram-positive bacteria was not a clinical problem.


Staphylococcus Aureus Fusidic Acid Methicillin Resistance Hospital Infection Vancomycin Resistance 
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© Springer-Verlag Italia, Milano 2001

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  • G. L. French

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