Multi-Resistant Gram-Negative Bacilli: Impact of Antibiotic Restriction

  • P. Toltzis
Conference paper
Part of the Topics in Anaesthesia and Critical Care book series (TIACC)


Infections with gram-negative bacilli that are resistant to one or more classes of parenteral antibiotics have become increasingly common over the past decade [1]. These bacteria express resistance to the broad-spectrum b-lactam agents, amino-glycosides, or quinolones through different molecular mechanisms, which may coexist within the same organism. They are isolated most frequently in large teaching hospitals [2] and are commonly found in intensive care units (ICU) [3, 4]. Indeed, since broad-spectrum antibiotics are disproportionately used in the ICU, it is widely held that many of these organisms originate there. This has generated considerable interest in testing antibiotic utilization policies for hospitals in general, and the ICU in particular, designed to lower the incidence of colonization or infection with antibiotic-resistant gram-negative bacteria [5, 6]. This chapter will describe two of these policies and the data supporting their effectiveness.


Intensive Care Unit Clin Infect Resistant Organism Aminoglycoside Resistance Antibiotic Restriction 
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© Springer-Verlag Italia, Milano 2001

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  • P. Toltzis

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