Skip to main content

Placental transfer of pharmacological agents

  • Chapter
Regional Anaesthesia Analgesia and Pain Management

Part of the book series: Topics in Anaesthesia and Critical Care ((TIACC))

  • 176 Accesses

Abstract

The placenta acts as an interface between maternal and fetal circulations. It transmits biological substances essential for fetal growth and development. Drugs cross the placenta by diffusing at varying rates, depending on their physical and chemical properties. Nonionized particles cross more rapidly than ions and small molecules more rapidly than large ones.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bonica JJ, Mc Donald JS (1995) Principles and practice of obstetric analgesia and anaes-thesia. Williams and Wilkins, Baltimore, pp 176–186

    Google Scholar 

  2. Pacifici GM, Nottoli R (1995) Placental transfer of drugs administered to the mother Clin Pharmacokinet 28 235–269

    CAS  Google Scholar 

  3. Decocq G, Brazier M, Hary L, Hubau C, Fortaine MR, Gondry J, Andrelak M (1997) Fundam Clin Pharmacol 11: 365–370

    Article  PubMed  CAS  Google Scholar 

  4. Kaneko T, Iwama H, Tobishima S, Watanabe K, Komatsu T, Tacheichi K, Tase C (1997) Placental transfer of vecuronium administered with priming principle regimen in patients undergoing Caesarian section JPEN J Anaesthesiol 46: 750–754

    CAS  Google Scholar 

  5. Fernando R, Bonello E, Gill P, Urquhart J, Reynolds F, Morgan B (1997) Neonatal welfare and placental transfer of fentanyl and bupivacaine during ambulatory combined spinal-epidural analgesia for labour. Anaesthesia 52: 517–524

    Article  PubMed  CAS  Google Scholar 

  6. Johnson RF, Herman N, Arney TL, Johnson HV, Paschall RL, Downing JW (1997) The placental transfer of sufentanil: effects of fetal pH, protein binding, and sufentanil concentration. Anaesth Analg 84: 1262–1268

    CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1999 Springer Verlag Italia, Milano

About this chapter

Cite this chapter

Margaria, E., Castelletti, I., Petruzzelli, P. (1999). Placental transfer of pharmacological agents. In: Tiengo, M., Paladini, V.A., Rawal, N. (eds) Regional Anaesthesia Analgesia and Pain Management. Topics in Anaesthesia and Critical Care. Springer, Milano. https://doi.org/10.1007/978-88-470-2240-9_9

Download citation

  • DOI: https://doi.org/10.1007/978-88-470-2240-9_9

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-0044-5

  • Online ISBN: 978-88-470-2240-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics