Clinical pharmacology of local anaesthetic agents

  • L. E. Mather
  • D. H.-T. Chang
Part of the Topics in Anaesthesia and Critical Care book series (TIACC)


Local anaesthetic agents (LAAs) are defined as those agents which, when applied in the region of a neuronal structure, reversibly prevent its conduction, thereby producing an absence of sensation in the region innervated. Substances that are irreversible or otherwise neurolytic or act by systemic mechanisms clearly do not fit the definition. It may be reasonably added that they should do this predictably and with an acceptable difference between therapeutic and toxic doses but, for these agents, tissue toxicity is evaluated as foremost. Hence evaluation of the therapeutic index (defined in traditional pharmacological terms as the ratio of lethal to therapeutic doses) is not the primary question although it is the secondary question for agents passing the test of tissue toxicity. Only those LAAs that do not cause tissue toxicity can be further considered for their other pharmacological properties.


Local Anaesthetic Agent Total Body Clearance Conjugate Acid Tissue Toxicity Local anaesthetICs 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Verlag Italia, Milano 1999

Authors and Affiliations

  • L. E. Mather
  • D. H.-T. Chang

There are no affiliations available

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