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Neurochemical memory in pain circuits

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Regional Anaesthesia Analgesia and Pain Management

Part of the book series: Topics in Anaesthesia and Critical Care ((TIACC))

Abstract

The pathophysiology of pain syndromes refers to two groups of experimental models aimed to mimic inflammatory and neuropathic pain [1]. In the first case, an overstimulation of peripheral nociceptors leads to pain sensation and to abnormal sensory modalities characterized by changes in quality sensation, like allodynia or increased response to painful stimuli such as hyperalgesia. In the second case, a lesion of peripheral or central pain pathways causes persistent pain that also comprises aberrant somatosensory processes, such as the phantom limb. In inflammatory pain, pain fibres are intact and no anatomical rearrangements in spinal and supraspinal tracts are present. In contrast, in neuropathic pain all tracts involved in pain transmission undergo severe anatomical rearrangements that take part in pain syndrome generation and evolution.

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Authors
  1. L. Calzà
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  2. M. Pozza
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  3. M. Zanni
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Editor information

Editors and Affiliations

  1. University of Milan, Milan, Italy

    M. Tiengo MD (Professor Emeritus) (Professor Emeritus)

  2. Department of Anaesthesia, Intensive Care and Pain Therapy, University of Trieste, Cattinara Hospital, Trieste, Italy

    V. A. Paladini MD

  3. Department of Anaesthesiology and Intensive Care, Orebro University Hospital, Orebro, Sweden

    N. Rawal MD

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© 1999 Springer Verlag Italia, Milano

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Calzà, L., Pozza, M., Zanni, M. (1999). Neurochemical memory in pain circuits. In: Tiengo, M., Paladini, V.A., Rawal, N. (eds) Regional Anaesthesia Analgesia and Pain Management. Topics in Anaesthesia and Critical Care. Springer, Milano. https://doi.org/10.1007/978-88-470-2240-9_2

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  • DOI: https://doi.org/10.1007/978-88-470-2240-9_2

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-0044-5

  • Online ISBN: 978-88-470-2240-9

  • eBook Packages: Springer Book Archive

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