Opioid drugs have not changed dramatically in the last 10 years and any progress is limited to a better knowledge of the characteristics of opioids as a group and of single drugs for specific properties. In conclusion, we are being helped more and more in making a choice that can best join efficacy and safety in each single therapeutic challenge that requires opioid drugs. As a matter of fact, the improvement in our use of these drugs has also suggested that they can be used safely, if necessary, for pathological conditions, previously considered not amenable to treatment with opioids, e.g. non-oncologic chronic pain. However, in this case it is even more important than in the case of oncologic pain to have a deep knowledge of each of the particular characteristics of each drug. Most of all, it is important to know the receptor specificity of each drug and its pharmacodynamic effects, also those not directly amenable to an interaction with opioid receptors .
KeywordsNeuropathic Pain Opioid Receptor Immunosuppressive Effect Immunostimulatory Effect Opioid Drug
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