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Introduction

  • M. Filippi
  • M. Rovaris
  • G. Comi
Part of the Topics in Neuroscience book series (TOPNEURO)

Abstract

Since the earliest clinical studies of multiple sclerosis (MS), it has been recognized that a subgroup of patients follows a pattern of disease evolution which is progressive from onset and, as a consequence, has been termed “primary progressive” (PP). Although only 10%–15% of the overall MS patient population is affected by PPMS, this condition on the one hand poses intriguing questions about the nature of the pathophysiological mechanisms underlying the progressive accumulation of neurological disability, and on the other represents an important clinical challenge.

Keywords

Multiple Sclerosis Magnetic Resonance Imaging Finding Glatiramer Acetate Functional Magnetic Resonance Imaging Neurological Disability 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Italia, Milano 2002

Authors and Affiliations

  • M. Filippi
  • M. Rovaris
  • G. Comi

There are no affiliations available

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