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Sepsis and Organ Dysfunction pp 85–102Cite as

Identification and Characterization of Protein Tyrosine Phosphatases Expressed in Human Neutrophils

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Abstract

The neutrophil is an important component of the innate immune system responsible for host defense. In this regard, it has a dual function: to destroy pathogenic microorganisms and to remove inflammatory debris. This functional role is achieved through a series of rapid and coordinated responses that include chemotaxis, phagocytosis, and intracellular killing of invading microorganisms. The latter is accomplished by release of a variety of microbicidal enzymes and cationic proteins contained in granules (exocytosis) and by production of reactive oxygen intermediates by the NADPH oxidase [1, 2]. In certain situations however, these toxic compounds can injure host tissues as is believed to occur in disorders characterized by inflammatory damage such as rheumatoid arthritis [3], inflammatory bowel disease [4, 5], and acute lung injury [6–8]. Thus to maintain homeostasis and minimize tissue damage, leukocyte microbicidal responses must be precisely regulated by processes including selective triggering and rapid termination of activation cascades once the initial stimulus has been removed. Currently the mechanisms which regulate neutrophil activation are incompletely understood.

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Authors
  1. J. Kruger
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  2. T. Fukushima
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  3. G. P. Downey
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Editor information

Editors and Affiliations

  1. Department of Surgery, Health Sciences Center, Saint Louis University, St. Louis, USA

    A. E. Baue M.D.

  2. Department of Clinical Sciences, Section of Anaesthesia, Intensive Care and Pain Clinic, Trieste University Medical School, Trieste, Italy

    G. Berlot M.D.  & A. Gullo M.D.  & 

  3. Department of Intensive Care, Erasme University Hospital Free University of Brussels, Belgium

    J.-L. Vincent M.D.

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© 2001 Springer-Verlag Italia, Milano

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Kruger, J., Fukushima, T., Downey, G.P. (2001). Identification and Characterization of Protein Tyrosine Phosphatases Expressed in Human Neutrophils. In: Baue, A.E., Berlot, G., Gullo, A., Vincent, JL. (eds) Sepsis and Organ Dysfunction. Springer, Milano. https://doi.org/10.1007/978-88-470-2229-4_9

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  • DOI: https://doi.org/10.1007/978-88-470-2229-4_9

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-0137-4

  • Online ISBN: 978-88-470-2229-4

  • eBook Packages: Springer Book Archive

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