Bad and Good News in Pathophysiology, Prevention, and Management of Sepsis
To date, models that describe the interactions of inflammatory mediators during severe sepsis are dominated by a single mediator (e.g. IL-1 or TNF) and often fail to account for the redundancy and interdependence of inflammatory responses. The net response elicited by a cytokine on a target cell is not an isolated event, but depends on the state of cell-associated cytokine receptors (which may be up or down-regulated) and the presence of other pro-inflammatory and counter-regulatory molecules. Ascribing qualifiers of benefit or harm to any inflammatory mediator (e.g. IL-1 or TNR) depends on the clinical context and the net effects of change over time during an infection.
KeywordsSeptic Shock Severe Sepsis Acute Lung Injury Good News Noninvasive Positive Pressure Ventilation
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