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Nitric Oxide: Lessons Learned and Areas of Success

  • W. M. Zapol
  • R. Jenney
Conference paper

Abstract

Pulmonary hypertension with severe hypoxemia complicates the care of patients with diseases such as acute respiratory distress syndrome (ARDS), pulmonary embolism, chronic respiratory failure, chronic pulmonary hypertension, and after cardiopulmonary bypass. Pulmonary hypertension is also common in newborn patients with prematurity, meconium aspiration, pneumonia, sepsis, and congenital diaphragmatic hernias and in infants and children with many forms of congenital heart disease. Currently available intravenous vasodilator therapies often cause untoward effects when used to reduce pulmonary hypertension. For example, systemic vasodilatation and hypotension occur with all vasodilators infused at dosages sufficient to decrease pulmonary hypertension. In addition, intravenous infusions of systemic vasodilators often increase the venous admixture due to right to left shunting of venous blood. It is extremely desirable to identify a vasodilator that selectively relaxes constricted pulmonary arteries, and does not cause systemic dilatation or increased pulmonary venous admixture.

Keywords

Nitric Oxide Nitric Oxide Pulmonary Hypertension Acute Respiratory Distress Syndrome Pulmonary Artery Pressure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Italia, Milano 2001

Authors and Affiliations

  • W. M. Zapol
  • R. Jenney

There are no affiliations available

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