• Francesco Capasso
  • Timothy S. Gaginella


Millions of persons worldwide suffer from difficult or painful defecation, known commonly as constipation. Although the frequency of bowel movements varies greatly among normal healthy individuals, it is usual for those with constipation to voluntarily (because of physical discomfort) or involuntarily (because of disease, drugs or the stress of daily life) delay defecation. The absence of enough fiber in the diet, the lack of physical exercise and insufficient fluid intake also contribute to constipation.


Intestinal Tract Bowel Movement Physical Discomfort Magnesium Salt Normal Healthy Individual 
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Copyright information

© Springer-Verlag Italia, Milano 1997

Authors and Affiliations

  • Francesco Capasso
    • 1
  • Timothy S. Gaginella
    • 2
  1. 1.Department of Experimental PharmacologyUniversity of Naples “Federico II”NaplesItaly
  2. 2.School of PharmacyUniversity of WisconsinMadisonUSA

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