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To Treat or Not To Treat Ventricular Arrhythmias in Dilated Cardiomyopathy?

  • D. Bracchetti
  • M. Mezzetti
  • G. Barbato
  • N. Franco
  • G. Casella
Conference paper

Abstract

The management of patients (pts) with dilated cardiomyopathy (DC) and malignant ventricular arrhythmias (MVA), with particular attention to their treatment indication, should include a comprehensive clinical evaluation focusing on the potential role of triggering factors of rhythm disturbances. The clinical evaluation of the various interrelated adverse events that can precipitate MVA, as shown in Fig.1, is mandatory for the full understanding of the clinical problems of these pts. DC is characterized by a progressive dilatation of cardiac chambers, but principally of the left ventricle, together with poor and inadequate wall hypertrophy and severe reduction of myocardial contractility and overall ventricular function. Ischemic cardiomyopathy (ICM) and idiopathic cardiomyopathy (DCM) are the most common forms, but the etiology is often multifactorial. Death is caused by progressive heart failure, with mortality rates ranging from 30% to 50% at 1 year from symptom onset, or sudden cardiac death (SCD) presumably resulting from arrhythmias, accounting for 28%–45% of fatal events (1, 2). SCD could be ascribed in most cases to ventricular tachycardia (VT) degenerating into ventricular fibrillation (VF; 3). Previous observations warrant addressing the issue of treatment of pts with DC and MVA.

Keywords

Ventricular Arrhythmia Antiarrhythmic Drug Antiarrhythmic Agent Negative Inotropic Effect Holter Monitoring 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Italia, Milano 1996

Authors and Affiliations

  • D. Bracchetti
    • 1
  • M. Mezzetti
    • 1
  • G. Barbato
    • 1
  • N. Franco
    • 1
  • G. Casella
    • 1
  1. 1.Divisione di CardiologiaOspedale MaggioreBolognaItaly

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