What Have We Learned from the SWORD Trial? Can Potassium Channel Blockers Reduce Sudden Cardiac Death?

  • P. J. Schwartz
Conference paper


On November 1, 1994, the SWORD (Survival With Oral D-sotalol) trial was terminated by the Steering Committee because of an excess mortality among the patients randomized to d-sotalol. Five years after the early termination of the Cardiac Arrhythmia Suppression Trial (CAST) for similar reasons, this event has caused further concern in the field of cardiac arrhythmias and electrophysiology and is raising questions about the availability of drugs that may reduce sudden cardiac death and also about the rationale and events that precede the initiation of large-scale clinical trials.


Heart Rate Variability Sudden Cardiac Death Ventricular Fibrillation Antiarrhythmic Drug Cardiac Arrhythmia Suppression Trial 
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Copyright information

© Springer-Verlag Italia, Milano 1996

Authors and Affiliations

  • P. J. Schwartz
    • 1
    • 2
  1. 1.Cattedra di Cardiologia Policlinico San Matteo IRCCSUniversità degli Studi di PaviaPaviaItaly
  2. 2.Istituto di Clinica Medica Generale e Terapia MedicaUniversità degli StudiMilanItaly

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