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Drug-Induced Esophagitis

  • Conference paper
Drug-Induced Injury to the Digestive System

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Abstract

Although drugs have been administered since antiquity, esophageal injuries caused directly by prolonged contact with tablets or capsules have only recently been recognized. The first case of esophageal ulceration following oral potassium therapy was described in 1970 [37]. Since then, many cases have been reported in the literature, and more than 50 drugs have been involved. Drug-induced esophagitis is observed only rarely, occurring in less than 1% of cases [18]. A survey of a population of 700,000 over a 4-year period in Sweden reported an incidence of 3,9 cases per 100,000 population per year [11]. Nevertheless, the incidence may be underestimated. Many cases are not reported since the course is usually favorable, and many more are probably unrecognized or attributed to other esophageal diseases, in spite of characteristic clinical features and endoscopic findings [7, 21]. Esophagoscopy is necessary for diagnosis, control of the complete mucosal healing, and detection of distant complications.

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References

  1. Abbarah TH, Fredeil JE, Ellenz GB (1976) Ulceration by oral ferrous sulfate. J Am Med Assoc 286: 2319–2320

    Google Scholar 

  2. Applegate GR, Malmud LS, Rock E et al (1980) “It’s a hard pill to swallow” or “don’t take it lying down”. Gastroenterology 78: 1132

    Google Scholar 

  3. Barrison IG, Trewby PN, Kane SP (1980) Esophageal ulceration due to emepronium bromide. Endoscopy 12: 197–199

    Article  PubMed  CAS  Google Scholar 

  4. Bailey RT, Bonavina L, Nwakama PE, De Meester TR, Cheng C (1990) Influence of dissolution rate and pH of oral medications on drug-induced esophageal injury. DICP, The Annals of Pharmacotherapy 24: 571–574

    CAS  Google Scholar 

  5. Becouarn Y, Lamouliatte H, Quinton A (1983) Lésions aiguës de l’œsophage d’origine médicamenteuse. Gastroenterol Clin Biol 7: 868–876

    PubMed  CAS  Google Scholar 

  6. Bonavina L, De Meester TR, MacChesney L et al (1987) Drug-induced esophageal strictures. Ann Surg 206:173–183

    Article  PubMed  CAS  Google Scholar 

  7. Bott S, Prakash C, MacCallum RW (1987) Medication-induced esophageal injury: survey of the literature. Am J Gastroenterol 82: 758–753

    PubMed  CAS  Google Scholar 

  8. Bova JG, Dutton NE, Goldstein HM et al (1987) Medication-induced esophagi-tis: diagnosis by double-contrast esophagography. AJR 148: 731–732

    PubMed  CAS  Google Scholar 

  9. Burrington JD (1975) Clinitest burns of the esophagus. Ann Thorac Surg 20: 400–404

    Article  PubMed  CAS  Google Scholar 

  10. Carlborg B, Densert O (1980) Esophageal lesions caused by orally administered drugs. An experimental study in the cat Eur Surg Res 12: 270–282

    CAS  Google Scholar 

  11. Carlborg B, Kumlien A, Olsson H (1978) Medikamentella esofagusstrikturer. Lakartidningen 75: 4609–4611

    PubMed  CAS  Google Scholar 

  12. Channer KS, Virjee J (1982) Effect of posture and drink volume on the swallowing of capsules. Br Med J 285: 1702

    Article  CAS  Google Scholar 

  13. Channer KS, Bell J, Virjee J (1984) Effect of left atrial size on the esophageal transit of capsules. Br Heart J 52: 223–227

    Article  PubMed  CAS  Google Scholar 

  14. Coates AG, Nostrandt TT, Wilson JA et al (1986) Esophagitis caused by nonsteroidal antiinflammatory medication: case reports and review of literature on pill-induced esophageal injury. South Med J 79: 1094–1097

    Article  PubMed  CAS  Google Scholar 

  15. Delpre G, Kadish U (1981) More on esophageal ulcerations due to tetracycline and doxycycline therapy. Gastrointest Endosc 27: 108–109

    Article  PubMed  CAS  Google Scholar 

  16. Delpre G, Kadish U, Stahl B (1989) Induction of esophageal injuries by doxycycline and other pills. A frequent but preventable occurrence. Dig Dis Sci 34: 797–800

    Article  PubMed  CAS  Google Scholar 

  17. Edwards P, Turner J, Gold J, Cooper DA (1990) Esophageal ulceration induces by zidovudine. Ann Intern Med 112: 65–66

    PubMed  CAS  Google Scholar 

  18. Eichenberger P, Blum AL (1980) Drug-induced esophageal lesions. Acta Endosc 10: 273–278

    Article  Google Scholar 

  19. Eng J, Sabanathan S (1991) Drug-induced esophagitis. Am J Gastroenterol 86: 1127–1133

    PubMed  CAS  Google Scholar 

  20. Evans KT, Roberts GM (1976) Where do all tablets go? Lancet 2: 1237–1239

    Article  PubMed  CAS  Google Scholar 

  21. Florent C, Chagnon JP, Vivet P, Brun JG, Cattan D, Bernier JJ (1980) Accidents œsophagiens associés à la prise de doxycycline. Gastroenterol Clin Biol 4: 888–892

    PubMed  CAS  Google Scholar 

  22. Giger M, Sonnenberg A, Brandli H, Singeisen M, Guller R, Blum AL (1978) Das Tetracyclin Ulkus der Speiseröhre. Dtsch Med Wochenschr 103: 1038–1040

    Article  PubMed  CAS  Google Scholar 

  23. Goff JS, Satterlee W (1985) Sucralfate and esophageal ulcers. Gastrointest Endosc 31: 50

    Article  PubMed  CAS  Google Scholar 

  24. Habeshaw T, Bennett JR (1972) Ulceration of mouth due to emepronium bromide. Lancet 1:493

    Google Scholar 

  25. Heller SR, Fellows IW, Ogilvie AL, Atkinson M (1982) Nonsteroidal antiinflammatory drugs and benign esophageal stricture. Br Med J 285: 167–168

    Article  CAS  Google Scholar 

  26. Hey H, Jorgensen F, Sorensen K, Hasselbach H, Warnberg T (1982) Esophageal transit of six commonly used tablets and capsules. Br Med J 285:1717–1719

    Article  CAS  Google Scholar 

  27. Kikendall JW, Friedman AC, Oyewole MA, Fleischer D, Johnson LF (1983) Pill-induced esophageal injury. Case reports and review of the medical literature. Dig Dis Sci 28: 174–182

    Article  PubMed  CAS  Google Scholar 

  28. Lauder AD (1979) Cetipirin and esophageal ulceration. Br Med J 2: 211

    Article  PubMed  CAS  Google Scholar 

  29. MacCall AJ (1975) Slow-K ulceration of esophagus with aneurysmal left atrium. Br Med J 3: 230–231

    Article  Google Scholar 

  30. MacCord GS, Clouse RE (1990) Pill-induced esophageal strictures: clinical features and risk factors for development. Am J Med 88: 512–518

    Article  Google Scholar 

  31. Minocha A, Greenbaum DS (1991) Pill-esophagitis caused by nonsteroidal antiinflammatory drugs. Am J Gastroenterol 86: 1086–1089

    PubMed  CAS  Google Scholar 

  32. O’Meara TF (1980) A new endoscopic finding of tetracycline induced ulcers. Gastrointest Endosc 26: 106–107

    Article  PubMed  Google Scholar 

  33. Orr WC, Johnson LF, Robinson MG (1984) Effect of sleep on swallowing, esophageal peristaltis, and acid clearance. Gastroenterology 86: 814–819

    PubMed  CAS  Google Scholar 

  34. Ovartlarnporn B, Kulwichit W, Hiranniramol S (1991) Medication-induced esophageal injury: report of 17 cases with endoscopic documentation. Am J Gastroenterol 86: 748–750

    PubMed  CAS  Google Scholar 

  35. Papazian A, Capron JD, Dupas JL (1981) Doxycycline-induced esophageal ulcer. Value of Lugol’s solution vital staining. Gastrointest Endosc 27: 201

    Article  PubMed  CAS  Google Scholar 

  36. Papazian A, Descombes P, Capron JP (1984) Œsophagite ulcérée et mycotique après prise de Physiomycine. Gastroenterol Clin Biol 8: 389

    PubMed  CAS  Google Scholar 

  37. Pemberton J (1970) Esophageal obstruction and ulceration caused by oral potassium therapy. Br Heart J 32: 267–268

    Article  PubMed  CAS  Google Scholar 

  38. Pilbrant A (1977) Ulceration due to emepronium bromide tablets. Lancet 1: 749

    Article  PubMed  CAS  Google Scholar 

  39. Pinos T, Figueras C, Mas R (1990) Doxycycline-induced esophagitis: treatment with liquid sucralfate. Am J Gastroenterol 85: 902–903

    PubMed  CAS  Google Scholar 

  40. Rosenthal T, Adar R, Militanu J, Deutsch V (1974) Esophageal ulceration and oral potassium chloride ingestion. Chest 65: 463–465

    Article  PubMed  CAS  Google Scholar 

  41. Schreiber JB, Covington JA (1988) Aspirin-induced esophageal hemorrhage. JAMA 259: 1647–1648

    Article  PubMed  CAS  Google Scholar 

  42. Semble EL, Wu WC, Castell DO (1989) Nonsteroidal antiinflammatory drugs and esophageal injury. Semin Arthritis Rheum 19: 99–109

    Article  PubMed  CAS  Google Scholar 

  43. Spiller RC (1986) Where do all tablets go in 1986? Gut 27: 879–885

    Article  PubMed  CAS  Google Scholar 

  44. Williams JG (1979) Drug-induced esophageal injury. Br Med J 2: 273

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Service des Maladies de l’Appareil digestif, Hôpital Saint-André, Bordeaux, France

    A. Quinton, F. Zerbib & H. Lamouliatte

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  1. A. Quinton
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  2. F. Zerbib
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  3. H. Lamouliatte
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© 1993 Springer-Verlag Berlin Heidelberg

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Quinton, A., Zerbib, F., Lamouliatte, H. (1993). Drug-Induced Esophagitis. In: Drug-Induced Injury to the Digestive System. Springer, Milano. https://doi.org/10.1007/978-88-470-2220-1_2

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  • DOI: https://doi.org/10.1007/978-88-470-2220-1_2

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-2222-5

  • Online ISBN: 978-88-470-2220-1

  • eBook Packages: Springer Book Archive

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