Indications for continuous renal replacement therapy in sepsis
Sepsis continues to provide a major challenge to clinicians and, despite vast advancements in the understanding of pathways and mechanisms, the incidence of sepsis is increasing and the mortality rate remains unaffected, generating a considerable burden to health budgets worldwide . Severe sepsis and septic shock are the most-common cause of multiple organ failure (MOF) . MOF remains the most-frequent cause of death in patients admitted to the intensive care unit, with a mortality rate exceeding 50% . The lung and liver are the most frequently involved organs in MOF. However, once acute renal failure (ARF) develops, the mortality exceeds 70% . Unfortunately to date, there is no definitive therapy that conclusively treats sepsis and its deleterious complications with convincing success. Thus, once MOF is established the treatment is essentially supportive while awaiting for homeostasis to re-establish.
KeywordsSeptic Shock Severe Sepsis Acute Renal Failure Systemic Inflammatory Response Syndrome Multiple Organ Failure
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