The neural and humoral response to acute neurological illness is the mechanism of consequent new organ failures

  • P. J. D. Andrews
Conference paper


The neural and humoral response to acute neurological illness is important during the initial onset, and while critical for the body to successfully deal with acute physical stressors such as low blood pressure, hypoxia etc., may have a deleterious effect after the acute phase. For example, glucocorticoid excess adversely affects the nervous system, particularly the hippocampus [1]. These effects include disruption of synaptic plasticity, atrophy of dendrites (i.e., reducing connections between neurones), compromise of the ability of neurones to survive various coincident insults, which are common after traumatic brain injury (TBI) [2].


Traumatic Brain Injury Head Injury Brain Natriuretic Peptide Atrial Natriuretic Peptide Multiple Organ Dysfunction Syndrome 
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© Springer-Verlag Italia 2003

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  • P. J. D. Andrews

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