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Early goal-directed therapy prevents organ failure and mortality in severe sepsis and septic shock

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Book cover Anaesthesia, Pain, Intensive Care and Emergency Medicine — A.P.I.C.E.

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Abstract

The systemic inflammatory response syndrome can be self-limited or progress to severe sepsis and septic shock [1]. Along this continuum, circulatory abnormalities lead to an imbalance between systemic oxygen delivery and demands or global tissue hypoxia [2]. As a modulator to serious illness, global tissue hypoxia is a sentinel development preceding multiple system organ failure and death [2]. This transition to serious illness occurs during the proverbial “golden-hour” when definitive recognition and treatment provide maximum outcome benefit. However, these “golden-hours” can elapse in the emergency department [3], hospital ward [4], and even in the intensive care unit [5].

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Authors
  1. E. Rivers
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  2. B. Nguyen
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  3. S. Havstad
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Editor information

Editors and Affiliations

  1. Department of Perioperative Medicine, Intensive Care and Emergency, Trieste University School of Medicine, Trieste, Italy

    Antonino Gullo M.D. (Head) (Head)

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© 2003 Springer-Verlag Italia

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Rivers, E., Nguyen, B., Havstad, S. (2003). Early goal-directed therapy prevents organ failure and mortality in severe sepsis and septic shock. In: Gullo, A. (eds) Anaesthesia, Pain, Intensive Care and Emergency Medicine — A.P.I.C.E.. Springer, Milano. https://doi.org/10.1007/978-88-470-2215-7_38

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  • DOI: https://doi.org/10.1007/978-88-470-2215-7_38

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-0194-7

  • Online ISBN: 978-88-470-2215-7

  • eBook Packages: Springer Book Archive

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