Sepsis and the role of the human host
This is an exciting time in sepsis research. Not only do we understand more about the epidemiology and pathophysiology of sepsis than ever before, but due to recent successful therapeutic trials [1–3], we now have sepsis-specific dmgs that improve survival. However, even with these developments, there remain a significant number of challenges. The more we understand about the complexity of sepsis, the more we are required to reflect this complexity in our trials if they are to remain applicable to the average intensive care unit (ICU) patient. Unfortunately, determining all the relevant variables and following them for a sufficient period of time is both difficult and expensive. While these issues are not necessarily unique to intensive care, they play a particularly prominent role in sepsis research because of the nature of sepsis and its patient population.
KeywordsSevere Sepsis Systemic Inflammatory Response Syndrome Multiple Organ Dysfunction Score Acute Organ Dysfunction Sepsis Trial
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