Grading severity of sepsis
The ability to determine and grade the severity of any disease process provides a means of characterizing individual patients, enabling comparison of patient groups and assessment of the effects of treatment on morbidity and disease progression. Such techniques may be particularly useful in the clinical trial setting, but can also be applied to everyday clinical practice. We will briefly discuss recent concepts in definitions of sepsis, before concentrating on the grading of disease severity by measurement of organ dysfunction. Several scoring systems have been developed that allow analysis of the degree of individual and total organ dysfunction in such patients, and we will briefly discuss the basic rationale behind them before focusing in on the most widely used, the Sequential Organ Failure Assessment (SOFA) score.
KeywordsOrgan Dysfunction Sequential Organ Failure Assessment Severe Acute Pancreatitis Sequential Organ Failure Assessment Score Drotrecogin Alfa
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