Recent advances in mechanisms of action of general anaesthetics from genetically engineered animal models
Despite the use of general anaesthetics for well over a century, a mechanism(s) of action of these drugs on the nervous system that explains their behavioural effects has yet to be elucidated. What is the molecular site(s) and mechanism(s) of action of anaesthetics in the brain that cause amnesia and block response to painful stimuli? An understanding of this mechanism(s) could ultimately lead to improved anaesthetics with fewer side effects. In addition, understanding how these widely used drugs interfere with neuronal function may also lead to novel insight into many physiological and pathophysiological processes.
KeywordsGABAA Receptor General Anaesthetic Glycine Receptor Angelman Syndrome Knockin Mouse
Unable to display preview. Download preview PDF.
- 3.Quinlan JJ, Ferguson C, Jester K, et al (2002) Mice with glycine receptor subunit mutations are both sensitive and resistant to volatile anesthetics. Anesth Analg (in press)Google Scholar
- 5.Homanics GE (2002) Knockout and knockin mice. In: Liu Y, Lovinger DM, (eds) Methods for alcohol-related neuroscience research. CRC Press, Boca Raton, pp 31–60Google Scholar
- 6.Kralic JE, Korpi ER, O’Buckley TK, et al (2002) Molecular and pharmacologic characterization of GABAa receptor alpha-1 subunit knockout mice. J Pharmacol Exp Ther (in press)Google Scholar
- 8.Kralic JE, O’Buckley TK, Khisti RT, et al (2002) GABAa receptor alpha-1 subunit deletion alters benzodiazepine receptor assembly, pharmacological properties, and behavioral responses. Neuropharmacology Submitted Google Scholar