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2P domain K+ channels: novel targets for volatile general anaesthetics

  • E. Honorè
Conference paper

Abstract

The volatile anaesthetic-mediated hyperpolarization reduces cell excitability, increases synaptic input conductance, and may contribute to the depression of the central nervous system. Background K+ channels are encoded by the newly discovered family of 2P domain K+ channel subunits. Specific members of this family including TREK-1 and TASK-1, which are expressed in the central and peripheral nervous systems, can be reversibly opened by inhalation anaesthetics. Opening of the 2P domain K+ channels at both pre- and postsynaptic levels may contribute to unconsciousness, amnesia, analgesia, and immobility.

Keywords

Dorsal Root Ganglion Channel Subunit Cerebellar Granule Neuron Carboxy Terminus Pore Domain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Italia 2003

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  • E. Honorè

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