Epithelial Injury in Sepsis and ARDS: Role of Leukocyte-Derived Proteases
Research in the last 30 years has demonstrated that acute lung injury and sepsis are largely inflammatory diseases [1, 12]. This is correct whether or not the primary initiating factor directly induces acute inflammation (sepsis, disseminated intravascular coagulation, or pancreatitis) or whether there is direct injury to the lungs (hyperoxia or chemical injury). In the latter circumstances, although the initial injury may involve direct cellular cytotoxicity, the ensuing inflammatory response appears to be responsible for much of the morbidity and mortality associated with these entities [3, 4].
KeywordsTight Junction Acute Lung Injury Neutrophil Elastase Alveolar Space Epithelial Injury
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