Phagocytosis and Lung Injury

  • J. W. Booth
Conference paper


Phagocytosis of pathogens by macrophages and neutrophils is a key component of innate immunity, with internalization leading in most cases to killing of the pathogen. However, while phagocytosis is a crucial element of host defence, aspects of the phagocytic response can also be associated with host tissue damage. I will review our current understanding of the basic mechanisms of phagocytosis, and potential sources of deleterious effects on the host.


Lung Injury Azurophil Granule Proinflammatory Signalling Phagosome Maturation Phagocytic Receptor 
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© Springer-Verlag Italia, Milano 2002

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  • J. W. Booth

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