Septic Shock Therapy

  • R. Fumagalli
  • D. Codazzi
  • S. Cattaneo
Conference paper


Sepsis represents one of the pathological conditions that can develop during an intensive care unit (ICU) stay or can be the cause of admission to the ICU. In the past the lack of a commonly accepted definition of this pathology led to a common misinterpretation of morbility and mortality [1–3].


Septic Shock Severe Sepsis Systemic Inflammatory Response Syndrome Intensive Care Unit Patient Lactic Acidosis 
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  1. 1.
    Rangel-Fausto MS, Pittet D, Costigan M, et al (1995) The natural history of the systemic inflammatory response syndrome (SIRS). JAMA 273: 117–123CrossRefGoogle Scholar
  2. 2.
    Pittet D, Rangel-Frausto S, Li N, et al (1995) Systemic inflammatory response syndrome, sepsis, severe sepsis, and septic shock; incidence, morbidities and outcomes in surgical ICU patients. Intensive Care Med 21: 302–309PubMedCrossRefGoogle Scholar
  3. 3.
    Salvo I, Cian W de, Musicco M, et al (1995) The Sepsis Study Group. The Italian sepsis study: preliminary results on the incidence and evolution of SIRS, sepsis, severe sepsis, and septic shock. Intensive Care Med 21: 5244-S249CrossRefGoogle Scholar
  4. 4.
    Saez-Llorens X, Vargas S, Guerra F, Coronado L (1995) Application of new sepsis definitions to evaluate outcome of pediatric patients with severe systemic infections. Pediatr Infect Dis J 14: 557–561PubMedCrossRefGoogle Scholar
  5. 5.
    Proulx F, Fayon M, Farrell CA, et al (1996) Epidemiology of sepsis and multiple organ dysfunction syndrome in children. Chest 109: 1033–1037PubMedCrossRefGoogle Scholar
  6. 6.
    Jones GR, Lowes JA (1966) The systemic inflammatory response syndrome as a predictor of bacteraemia and outcome from sepsis. Q J Med 89: 515–522Google Scholar
  7. 7.
    Bossink AWJ, Groeneveld J, Hack CE, Thjjs LG (1998) Prediction of mortality in febrile medical patients. How useful are systemic inflammatory response syndrome and sepsis criteria? Chest 113: 1533–1541PubMedCrossRefGoogle Scholar
  8. 8.
    Bone RC, Blak RA, Cerra FB, et al (1992) American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definition for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 20: 864–874CrossRefGoogle Scholar
  9. 9.
    Sugerman HJ (1971) Physiologic management of septicemic shock in man. Surg Forum 22: 3–5PubMedGoogle Scholar
  10. 10.
    Bochud P-Y (2001) Antibiotics in sepsis. Intensive Care Med 9 [Supp 1]: S36Google Scholar
  11. 11.
    Radetsky M (1994) The timing of antimicrobial therapy and outcome in serious bacterial infection. Curr Opin Infect Dis 7: 341–344CrossRefGoogle Scholar
  12. 12.
    Landry DW (2001) The pathogenesis of vasodilatory shock. N Engl J Med 345: 588–595PubMedCrossRefGoogle Scholar
  13. 13.
    Landry DW (1997) Vasopressin pressor hypersensitivity in vasodilatory shock. Crit Care 25: 1279–1282CrossRefGoogle Scholar
  14. 14.
    Annane D (2000) A 3 level prognostic classification in septic shock based on cortisol levels and cortisol response to corticotropin. JAMA 283: 1038–1045PubMedCrossRefGoogle Scholar
  15. 15.
    Johnston CA, Greinsman SE (1984) Endotoxemia induced by antibiotic therapy: a mechanism for adrenal corticosteroid protection in gram-negative sepsis. Trans Assoc Am Physicians 97: 172–181PubMedGoogle Scholar
  16. 16.
    Bernard GR, Vincent J-L, Laterre P-F, et al (2001) Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 344: 699–709PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Italia, Milano 2002

Authors and Affiliations

  • R. Fumagalli
  • D. Codazzi
  • S. Cattaneo

There are no affiliations available

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