Abstract
The study of cerebrospinal fluid (CSF) cells in multiple sclerosis (MS) has been closely linked to progress in the field of general immunology. In the mid-70s, with the advent of the idea that MS was an immunologically-mediated disease (or, at least, that an immunological process was at the basis of its pathogenesis), there was a sudden fluorishing of research on CSF cells. In those years, immunological methods used to distinguish B from T lymphocytes were applied to CSF cells, in order to establish the relative percentage of T and B lymphocyte subsets. The challenge was to find some numerical or functional abnormality to explain the high production of IgG in MS CSF.
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© 1996 Springer-Verlag Italia, Milano
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Marrosu, M.G. (1996). Lymphocyte subsets in multiple sclerosis cerebrospinal fluid. In: Cerebrospinal Fluid Analysis in Multiple Sclerosis. Springer, Milano. https://doi.org/10.1007/978-88-470-2205-8_6
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DOI: https://doi.org/10.1007/978-88-470-2205-8_6
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