Lymphocyte subsets in multiple sclerosis cerebrospinal fluid
The study of cerebrospinal fluid (CSF) cells in multiple sclerosis (MS) has been closely linked to progress in the field of general immunology. In the mid-70s, with the advent of the idea that MS was an immunologically-mediated disease (or, at least, that an immunological process was at the basis of its pathogenesis), there was a sudden fluorishing of research on CSF cells. In those years, immunological methods used to distinguish B from T lymphocytes were applied to CSF cells, in order to establish the relative percentage of T and B lymphocyte subsets. The challenge was to find some numerical or functional abnormality to explain the high production of IgG in MS CSF.
KeywordsMultiple Sclerosis Cerebrospinal Fluid Optic Neuritis Lymphocyte Subset Aseptic Meningitis
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