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Lymphocyte subsets in multiple sclerosis cerebrospinal fluid

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Cerebrospinal Fluid Analysis in Multiple Sclerosis

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Abstract

The study of cerebrospinal fluid (CSF) cells in multiple sclerosis (MS) has been closely linked to progress in the field of general immunology. In the mid-70s, with the advent of the idea that MS was an immunologically-mediated disease (or, at least, that an immunological process was at the basis of its pathogenesis), there was a sudden fluorishing of research on CSF cells. In those years, immunological methods used to distinguish B from T lymphocytes were applied to CSF cells, in order to establish the relative percentage of T and B lymphocyte subsets. The challenge was to find some numerical or functional abnormality to explain the high production of IgG in MS CSF.

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Authors and Affiliations

  1. II Chair of Paediatric Neuropsychiatry, Department of Neuroscience, University of Cagliari, Via Ospedale 119, 09124, Cagliari, Italy

    M. G. Marrosu

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  1. M. G. Marrosu
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© 1996 Springer-Verlag Italia, Milano

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Marrosu, M.G. (1996). Lymphocyte subsets in multiple sclerosis cerebrospinal fluid. In: Cerebrospinal Fluid Analysis in Multiple Sclerosis. Springer, Milano. https://doi.org/10.1007/978-88-470-2205-8_6

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  • DOI: https://doi.org/10.1007/978-88-470-2205-8_6

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-2207-2

  • Online ISBN: 978-88-470-2205-8

  • eBook Packages: Springer Book Archive

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