Evaluation of blood cerebrospinal fluid barrier function and quantification of the humoral immune response within the central nervous system

  • H. Reiber


The detection of disease-related changes in the brain is the basic target of cerebrospinal fluid (CSF) analysis. Besides cell count and cell differentiation, basic information is provided from proteins in CSF, in particular by detection of intrathecally synthesized immunoglobulin fractions in CSF. For the most sensitive quantification of a brainderived CSF protein fraction, besides the corresponding blood-derived fraction in CSF we need to take into account the blood CSF barrier function and in particular the variations of CSF flow rate.


Arachnoid Villus Intrathecal Synthesis Molecular Flux Albumin Quotient Intrathecal Immune Response 
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Copyright information

© Springer-Verlag Italia, Milano 1996

Authors and Affiliations

  • H. Reiber
    • 1
  1. 1.Laboratory of NeurochemistryUniversity of GöttingenGöttingenGermany

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