The detection of IgA, IgM and free light chains abnormalities in cerebrospinal fluid
The discrete bands observed in the cathodic region of agar gel electrophoresis in most CSF from MS patients  represent mainly IgG produced by a limited number of B-cell clones. The term oligoclonal as proposed by Laterre in 1965  is now widely accepted to define these bands present in CSF but not in blood. Already in 1977, some of these bands have been identified as free kappa or lambda light chains . In addition, we know that a minority of these IgG bands are actually directed against various neurotropic viruses, such as measles, rubella, varicella zoster and mumps . All these infections are very common during childhood and probably affect the brain more frequently than clinically observed. They probably induce the recruitment of specific B-cells within the central nervous system (CNS) and their persistence as memory cells. The MS process could lead to the reactivation of these memory B-cells and to a “polyspecific” production of antibodies against some of these neurotropic viruses.
KeywordsMultiple Sclerosis Free Light Chain Neurotropic Virus Intrathecal Synthesis Free Kappa Light Chain
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