The detection and significance of cerebrospinal fluid oligoclonal IgG

  • G. Giovannoni
  • E. J. Thompson


Multiple sclerosis (MS) is characterised pathologically by inflammation, demyelination and variable degrees of axonal loss and gliosis. The inflammation tends to be perivascular and consists predominantly of macrophages, activated microglia, T and B lymphocytes, and occasional plasma cells. These plasma cells are responsible for the production of oligoclonal immunoglobulin (Ig) within the central nervous system (CNS), and the detection of this abnormal IgG in the cerebrospinal fluid (CSF) is useful as one of the laboratory criteria supporting the clinical diagnosis of MS.


Multiple Sclerosis Oligoclonal Band Free Light Chain Definite Multiple Sclerosis Myelin Phagocytosis 
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Copyright information

© Springer-Verlag Italia, Milano 1996

Authors and Affiliations

  • G. Giovannoni
    • 1
  • E. J. Thompson
    • 1
  1. 1.Department of NeuroimmunologyInstitute of NeurologyLondonUK

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