Abstract
Multiple sclerosis (MS) is characterised pathologically by inflammation, demyelination and variable degrees of axonal loss and gliosis. The inflammation tends to be perivascular and consists predominantly of macrophages, activated microglia, T and B lymphocytes, and occasional plasma cells. These plasma cells are responsible for the production of oligoclonal immunoglobulin (Ig) within the central nervous system (CNS), and the detection of this abnormal IgG in the cerebrospinal fluid (CSF) is useful as one of the laboratory criteria supporting the clinical diagnosis of MS.
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© 1996 Springer-Verlag Italia, Milano
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Giovannoni, G., Thompson, E.J. (1996). The detection and significance of cerebrospinal fluid oligoclonal IgG. In: Cerebrospinal Fluid Analysis in Multiple Sclerosis. Springer, Milano. https://doi.org/10.1007/978-88-470-2205-8_3
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DOI: https://doi.org/10.1007/978-88-470-2205-8_3
Publisher Name: Springer, Milano
Print ISBN: 978-88-470-2207-2
Online ISBN: 978-88-470-2205-8
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