Desflurane [difluoromethyl-1-fluoro-2,2,2-trifluoroethyl ether (I-653)] was first introduced into clinical practice in the United States in the fall of 1992, and subsequently in several European countries (UK, France, Sweden, Finland, Denmark, Germany, Iceland, Luxembourg, Switzerland, Ireland, and Spain). The pharmacology of this anesthetic, which is chemically similar to isoflurane, was well-summarized by Eger (1) at the time of clinical introduction, as well as more recently (2). This description summarizes the current state of knowledge of the pharmacologic effects of desflurane, with an emphasis on the knowledge accumulated during the past 2 years.


Anesthetic Concentration Desflurane Anesthesia Desflurane Group Desflurane Concentration Autonomic Nervous System Blockade 


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© Springer-Verlag Italia, Milano 1996

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  • R. B. Weiskopf

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