Research Studies on Organ Perfusion: From the Lab to the Clinic

  • J.-L. Vincent
  • P. Van Der Linden
  • H. Zhang


A number of important medical questions cannot be addressed in patients for several reasons. First, the population is often too heterogeneous, with intricate underlying problems. Second, patients are usually seen when the disease state is already established so that the mechanisms of its development cannot be adequately studied and early interventions are impossible. Third, the methods necessary to the study may be too mutilating to be used in patients. In other words, the risk/benefit ratio is often too high for human application.


Septic Shock Methylene Blue Organ Perfusion Stagnant Hypoxia Disease Clinical Trial 
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Copyright information

© Springer-Verlag Italia, Milano 1996

Authors and Affiliations

  • J.-L. Vincent
  • P. Van Der Linden
  • H. Zhang

There are no affiliations available

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