Pancreas Dysfunction and Related Problems

  • G. Sganga
  • M. Castagneto
  • M. Soiat
  • A. Gullo


The pathophysiological changes following severe acute pancreatitis are well known.


Acute Pancreatitis Severe Acute Pancreatitis Multiple Organ Dysfunction Syndrome Pancreatic Acinar Cell Adult Respiratory Distress Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Ryan CM, Schmidt J, Lewandrowski K, Compton CC, Rattner DW, Warshaw AL, Tompkins RG (1993) Gut macromolecular permeability in pancreatitis correlates with severity of disease in rats. Gastroenterology 104:890–895PubMedGoogle Scholar
  2. 2.
    Warshaw AL, O’Hara PJ (1978) Susceptibihty of the pancreas to ischemic injury in shock. Ann Surg vol 178–11:197–201CrossRefGoogle Scholar
  3. 3.
    Hegewald G, Nikulin A, Gmaz-Nikulin E, Plamenac P, Barenwald G (1985) Ultrastructural changes of the human pancreas in acute shock. Path Res Pract 179:610–615PubMedCrossRefGoogle Scholar
  4. 4.
    Hesch M, Gnidec AA, Bersten AD, Troster M, Rutledge FS, Sibbald WJ (1990) Histologic and ultrastructural changes in nonpulmonary organs during early hyperdinamic sepsis. Surgery 107:397–410Google Scholar
  5. 5.
    Endrich B et al (1990) Gastrointestinal microcirculation. In: Messmer K, Hammersen F (eds) Prog Appl Microcirc. Basel Karger vol 17:141–174Google Scholar
  6. 6.
    Gmaz-Nikulin E, Nikulin A, Plamenac P, Hegewald G, Gaon D (1981) Pancreatic lesions in shock and their significance. J Pathology Vol 135:223–336CrossRefGoogle Scholar
  7. 7.
    Donath K, Mitschke H, Seifert H (1970) Ultrastrukturelle Veränderungen am Rattenpankreas beim hämorrhagischen Schock. Beitr Path Anat 141:33–51Google Scholar
  8. 8.
    Jones RT, Garcia JH, Mergner WJ, Pendergrass RE, Valigorsky JM, Trump BF (1975) Effects of shock on the pancreatic acinar cell. Arch Pathol 99:634–644PubMedGoogle Scholar
  9. 9.
    Fernandez-Del Castillo C, Harringer W, Warshaw AL, Vlahakes GJ, Kosky G, Zaslavsky AM, Rattner DW (1991) Risk factors for pancreatic cellular injury after cardiopulmonary bypass. N Engl J Med 325:382–387CrossRefGoogle Scholar
  10. 10.
    Warshaw AL, Bellini CA, Lee KH (1976) Electrophoretic identification of isoenzyme of amylase which increases in serum in liver diseases. Gastroenterology 70:572PubMedGoogle Scholar
  11. 11.
    Warshaw AL, Fuller AF Jr (1975) Specificity of increased renal clearance of amylase in diagnosis of acute pancreatitis. N Engl J Med 292:325PubMedCrossRefGoogle Scholar
  12. 12.
    Morrissey R, Berk JE, Fridhandler L, Pelot D (1974) Nature and significance of hyperamylasemia following operation. Ann Surg 180:67PubMedCrossRefGoogle Scholar
  13. 13.
    Warshaw AL (1976) The kidney and its changes in amylase clearance. Gastroenterology 71;4:702–704PubMedGoogle Scholar
  14. 14.
    Levette MD, Ellis C, Engel RR (1977) Isoelectric focusing studies of human serum and tissues isoamylase. J Lab Clin Med 90:141Google Scholar
  15. 15.
    Warshaw AL (1977) Serum amylase isoenzyme profiles as a differential index in disease. J Lab Clin Med 90:1PubMedGoogle Scholar
  16. 16.
    Deby-Dupont G, Haas M, Pincemail J, Braun M, Lamy M, Deby C, Franchimont P (1984) Immunoreactive trypsin in adult respiratory distress syndrome. Intensive Care Med 10: 7–12PubMedCrossRefGoogle Scholar
  17. 17.
    Lamy M, Deby-Dupont G (1994) The role of the pancreas in the multiple organ dysfunction syndrome. In: Hammerle AF (ed) MODS, Maudrich, Wien-Munchen-Bern, 68–69Google Scholar
  18. 18.
    Nicod L, Leuenberger PH, Seydoux C, Van Melle G, Perret CL (1985) Evidence for pancreas injury in adult respiratory distress syndrome. Am Rev Resp Dis 1131:696–699Google Scholar
  19. 19.
    Felber JP, Bambule-Dick J (1980) Radioimmunoessays of plasma trypsin in pancreatic diseases and in juvenile-onset diabetes. In: Podolsky S, Viswanathan M (eds) Secondary diabetes: the spectrum of the diabetic syndromes. Raven, New York, 180:191–196Google Scholar
  20. 20.
    Hammerschmidt DE, Harris PD, Wayland JH, Craddock PR, Jacob HS (1981) Complement-induced granulocyte aggregation in vivo. Am J Pathol 102:146–150PubMedGoogle Scholar
  21. 21.
    Lasson A, Ohlsson K (1986) Comsumptive coagulopathy, fibrinolysis and proteasi-antiproteasi interactions during acute human pancreatitis. Thromb Res 41(2): 167–183PubMedCrossRefGoogle Scholar
  22. 22.
    Ranson JH, Lackner H, Berman IR, Schinella R (1977) The relationship of coagulation factors to clinical complications of acute pancreatitis. Surgery 81(5):502–511PubMedGoogle Scholar
  23. 23.
    Clave P, Guillaumes S, Blanco I, Martines De Hurtado J, Esquius J, Marruecos L, Fontcubert AJ, Perez C, Farré A, Lluis F (1992) Splenic hematoma in acute pancreatitis. Role of coagulation disorders. Z Gastroenterol 30(8):538–542PubMedGoogle Scholar

Copyright information

© Springer-Verlag Italia, Milano 1996

Authors and Affiliations

  • G. Sganga
  • M. Castagneto
  • M. Soiat
  • A. Gullo

There are no affiliations available

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