Multivariable Physiologic Monitoring as a Guide to the Severity and Appropriate Therapy of Posttrauma ICU Patients
Clinical care and therapeutic decision making in the severely injured patient whose course is complicated by shock, sepsis or one of the various organ failure syndromes has been complicated by a lack of a precise methodology of classification of the nature of these disease processes and stratification of their severity. One important additional consequence of the lack of an effective methodology for stratification of critically ill patients with posttraumatic and/or septic syndromes into groups of homogeneous severity has been the paucity of significant advances in basic science mechanisms linking the production of various shock mediators to the different categories of the human host defense response. As a therapeutic consequence, the results of recent human clinical trials where a variety of antiendotoxin or anticytokine mediators have been tested in the therapy of sepsis have been either disappointing or equivocal in their outcome.
KeywordsSystemic Inflammatory Response Syndrome Mean Arterial Blood Pressure Sepsis Syndrome Host Defense Response Systemic Inflammatory Response Syndrome Criterion
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