Concept: Open Up the Lung and Keep the Lung Open

  • B. Lachmann


After more than 40 years of clinical use, artificial ventilation has proven to be a life-saving method or therapy in intensive care. Yet, it has remained a topic of much discussion and controversy because artificial ventilation involves a disturbance to normal respiratory and cardiovascular function.


Adult Respiratory Distress Syndrome Pressure Amplitude Artificial Ventilation Peak Inspiratory Pressure Ventilatory Mode 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Lachmann B, Danzmann E, Haendly B, Jonson B (1982) Ventilator settings and gas exchange in respiratory distress syndrome. In: Prakash O (ed) Applied physiology in clinical respiratory care. Martinus Nijhoff, The Hague, pp 141–176Google Scholar
  2. 2.
    Froese AB (1989) Role of lung volume in lung injury: HFO in the atelectasis-prone lung. Acta Anaesthesiol Scand 33 [Suppl 90]:126–130CrossRefGoogle Scholar
  3. 3.
    Sykes MK (1991) Does mechanical ventilation damage the lung? Acta Anaesthesiol Scand 35 [Suppl 95]:35–39CrossRefGoogle Scholar
  4. 4.
    Hickling KG (1990) Ventilatory management of ARDS: can it affect the outcome? Intensive Care Med 16:219–226PubMedCrossRefGoogle Scholar
  5. 5.
    Mead J, Takishima T (1970) Leith. Stress distribution in lungs: a model of pulmonary elasticity. J Appl Physiol 128:596–608Google Scholar
  6. 6.
    Spragg RG, Smith RM (1991) Biology of acute lung injury. In: Crystal RG, West JB, et al (eds) The lung: scientific foundation. Raven, New York, pp 2003–2017Google Scholar
  7. 7.
    Lichtwarck-Aschoff M, Nielsen JB, Sjöstrand UH, Edgren EL (1992) An experimental randomized study of five different ventilatory modes in a piglet model of severe respiratory distress. Intensive Care Med 18:339–347PubMedCrossRefGoogle Scholar
  8. 8.
    Houmes RJM, Bos JAH, Lachmann B (1994) Effect of different ventilator settings on lung mechanics: with special reference to the surfactant system. Appl Cardiopulm Pathophysiol 5:117–127Google Scholar
  9. 9.
    Bos JAH, Lachmann B (1992) Effects of artificial ventilation on surfactant function. In: Rligheimer E (ed) New aspects on respiratory failure, Springer, Berlin Heidelberg New York, pp 194–208CrossRefGoogle Scholar
  10. 10.
    Faridy EE (1976) Effect of distension on release of surfactant in excised dogs’ lungs. Respir Physiol 27:99–114PubMedCrossRefGoogle Scholar
  11. 11.
    Benzer H (1969) Respiratorbeatmung und Oberflächenspannung in der Lunge. In: Frey R, Kern F, Mayrhofer O (eds) Anaesthesiologie und Wiederbelebung, vol 38. Springer, Berhn Heidelberg New YorkGoogle Scholar
  12. 12.
    Guyton AC, Moffat DS, Adair TA (1980) Role of alveolar surface tension in transepithehal movement of fluid. In: Robertson B, Van Golde LMG, Batenburg JJ (eds) Pulmonary surfactant. Elsevier, Amsterdam, pp 171–185Google Scholar

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© Springer-Verlag Italia, Milano 1996

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  • B. Lachmann

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